2026-09-21T15:36:23Z salford-repository.worktribe.com

oai:salford-repository.worktribe.com:1337324 2026-06-03T21:33:42Z 084104101115105115 openaccess

Thesis Establishing a structure-activity-relationship for small molecule non-sugar glycomimetics DAOY Medullablastoma cells are highly invasive, mobile and can cause severe neurological and physical illness in patients affected by this cancer. Previous work by Wilkinson & Co-workers (2017) showed that some small-molecule non-sugar glycomimetic drugs were able to prevent wound healing in DAOY cells. Therefore establishing a SAR for these molecules was of interest.A number of mono, di, tri, tetra & poly-sulfated drug molecules were synthesised from easily available starting materials and reagents and tested for potency against wound healing in DAOY cells in a scratch assay against human growth factor/scatter factor (HGF/SF) as a control. Compounds trialled in scratch assays did not show any reasonable biological activity. HGF/SF has been shown to activate downstream signalling of the oncogene product c-Met which is a biomarker for cancer(s) and can be associated with poorer outcomes for patients. Dobiecki-Davies, J Master's Level (Level 7) 2021-03-31 oai:salford-repository.worktribe.com:1337324 https://salford-repository.worktribe.com/file/1337324/1/Joe%20Dobiecki-Davies%20MSc%20final%20copy.pdf Kidscan https://salford-repository.worktribe.com/output/1337324 2021 en openAccess Public