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All Outputs (18)

Vascular dementia: From pathobiology to emerging perspectives (2024)
Journal Article
Elizabeth Morgan, A., McAuley, M. T., & Tomás Mc Auley, M. (2024). Vascular dementia: From pathobiology to emerging perspectives. Ageing research reviews, 96, 102278. https://doi.org/10.1016/j.arr.2024.102278

Vascular dementia (VaD) is the second most common type of dementia. VaD is synonymous with ageing, and its symptoms place a significant burden on the health and wellbeing of older people. Despite the identification of a substantial... Read More about Vascular dementia: From pathobiology to emerging perspectives.

A new mathematical model of folate homeostasis in E. coli highlights the potential importance of the folinic acid futile cycle in cell growth. (2023)
Journal Article
Morgan, A., Salcedo-Sora, J. E., & Mc Auley, M. T. (2024). A new mathematical model of folate homeostasis in E. coli highlights the potential importance of the folinic acid futile cycle in cell growth. BioSystems, 235, 105088. https://doi.org/10.1016/j.biosystems.2023.105088

Folate (vitamin B9) plays a central role in one-carbon metabolism in prokaryotes and eukaryotes. This pathway mediates the transfer of one-carbon units, playing a crucial role in nucleotide synthesis, methylation, and amino acid homeostasis. The foli... Read More about A new mathematical model of folate homeostasis in E. coli highlights the potential importance of the folinic acid futile cycle in cell growth..

Computationally Modelling Cholesterol Metabolism and Atherosclerosis (2023)
Journal Article
Davies, C., Morgan, A. E., & Mc Auley, M. T. (2023). Computationally Modelling Cholesterol Metabolism and Atherosclerosis. Biology, 12(8), 1133. https://doi.org/10.3390/biology12081133

Cardiovascular disease (CVD) is the leading cause of death globally. The underlying pathological driver of CVD is atherosclerosis. The primary risk factor for atherosclerosis is elevated low-density lipoprotein cholesterol (LDL-C). Dysregulation of c... Read More about Computationally Modelling Cholesterol Metabolism and Atherosclerosis.

Cholesterol transport in blood, lipoproteins, and cholesterol metabolism (2022)
Book Chapter
Mc Auley, M. T., & Morgan, A. E. (2022). Cholesterol transport in blood, lipoproteins, and cholesterol metabolism. . Elsevier. https://doi.org/10.1016/B978-0-323-85857-1.00025-0

The aim of this chapter is to critically discuss recent work which has focused on the dynamics of cholesterol transport and its intersection with health. Firstly, we provide an overview of the main lipoproteins, and their role in whole-body cholester... Read More about Cholesterol transport in blood, lipoproteins, and cholesterol metabolism.

Electrochemically detecting DNA methylation in the EN1 gene promoter: Implications for understanding ageing and disease (2020)
Journal Article
Morgan, A. E., Acutt, K. D., & Mc Auley, M. (2020). Electrochemically detecting DNA methylation in the EN1 gene promoter: Implications for understanding ageing and disease. Bioscience Reports, 40(11), https://doi.org/10.1042/BSR20202571

There is a growing need for biomarkers which predict age-onset pathology. Although this is challenging, the methylome offers significant potential. Cancer is associated with the hypermethylation of many gene promoters, among which are developmental g... Read More about Electrochemically detecting DNA methylation in the EN1 gene promoter: Implications for understanding ageing and disease.

Cholesterol Homeostasis: An In Silico Investigation into How Aging Disrupts Its Key Hepatic Regulatory Mechanisms (2020)
Journal Article
Morgan, A. E., & Mc Auley, M. T. (2020). Cholesterol Homeostasis: An In Silico Investigation into How Aging Disrupts Its Key Hepatic Regulatory Mechanisms. Biology, 9(10), Article 314. https://doi.org/10.3390/biology9100314

The dysregulation of intracellular cholesterol homeostasis is associated with several age-related diseases, most notably cardiovascular disease (CVD). Research in this area has benefitted from using computational modelling to study the inherent compl... Read More about Cholesterol Homeostasis: An In Silico Investigation into How Aging Disrupts Its Key Hepatic Regulatory Mechanisms.

Systems-Based Mechanisms of Aging (2019)
Book Chapter
Proctor, C. J., Morgan, A. E., & Mc Auley, M. T. (2019). Systems-Based Mechanisms of Aging. In Encyclopedia of Biomedical Gerontology (332-345). Elsevier. https://doi.org/10.1016/B978-0-12-801238-3.11424-2

The last number of decades have witnessed an unrelenting global rise in the number of older people. This demographic shift is laudable; however, many older people are burdened by poor health. The main reason so many older people have their healthspan... Read More about Systems-Based Mechanisms of Aging.

The role of DNA methylation in ageing and cancer (2018)
Journal Article
Morgan, A. E., Davies, T. J., & Mc Auley, M. T. (2018). The role of DNA methylation in ageing and cancer. Proceedings of the Nutrition Society, 77(4), 412-422. https://doi.org/10.1017/S0029665118000150

The aim of the present review paper is to survey the literature related to DNA methylation, and its association with cancer and ageing. The review will outline the key factors, including diet, which modulate DNA methylation. Our rationale for conduct... Read More about The role of DNA methylation in ageing and cancer.

Modelling the molecular mechanisms of aging (2017)
Journal Article
Mc Auley, M., Guimera, A., Hodgson, D., Mcdonald, N., Mooney, K., Morgan, A., & Proctor, C. (2017). Modelling the molecular mechanisms of aging. Bioscience Reports, 37(1), https://doi.org/10.1042/BSR20160177

The aging process is driven at the cellular level by random molecular damage that slowly accumulates with age. Although cells possess mechanisms to repair or remove damage, they are not 100% efficient and their efficiency declines with age. There are... Read More about Modelling the molecular mechanisms of aging.

Investigating cholesterol metabolism and ageing using a systems biology approach (2016)
Journal Article
Morgan, A. E., Mooney, K. M., Wilkinson, S. J., Pickles, N. A., & Mc Auley, M. T. (2017). Investigating cholesterol metabolism and ageing using a systems biology approach. Proceedings of the Nutrition Society, 76(3), 378-391. https://doi.org/10.1017/S0029665116002822

CVD accounted for 27 % of all deaths in the UK in 2014, and was responsible for 1·7 million hospital admissions in 2013/2014. This condition becomes increasingly prevalent with age, affecting 34·1 and 29·8 % of males and females over 75 years of age... Read More about Investigating cholesterol metabolism and ageing using a systems biology approach.

Obesity and the dysregulation of fatty acid metabolism: implications for healthy aging (2016)
Journal Article
Morgan, A., Mooney, K., & Mc Auley, M. (2016). Obesity and the dysregulation of fatty acid metabolism: implications for healthy aging. Expert Review of Endocrinology and Metabolism, 11(6), 501-510. https://doi.org/10.1080/17446651.2016.1245141

Introduction: The population of the world is aging. In 2010, an estimated 524 million people were aged 65 years or older representing eight percent of the global population. By 2050, this number is expected to nearly triple to approximately 1.5 billi... Read More about Obesity and the dysregulation of fatty acid metabolism: implications for healthy aging.

Mathematically modelling the dynamics of cholesterol metabolism and ageing (2016)
Journal Article
Morgan, A., Mooney, K., Wilkinson, S., Pickles, N., & Mc Auley, M. (2016). Mathematically modelling the dynamics of cholesterol metabolism and ageing. BioSystems, 145, 19-32. https://doi.org/10.1016/j.biosystems.2016.05.001

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the UK. This condition becomes increasingly prevalent during ageing; 34.1% and 29.8% of males and females respectively, over 75 years of age have an underlying cardiovasc... Read More about Mathematically modelling the dynamics of cholesterol metabolism and ageing.

Cholesterol metabolism: A review of how ageing disrupts the biological mechanisms responsible for its regulation (2016)
Journal Article
Morgan, A., Mooney, K., Wilkinson, S., Pickles, N., & Mc Auley, M. (2016). Cholesterol metabolism: A review of how ageing disrupts the biological mechanisms responsible for its regulation. Ageing research reviews, 27, 108-124. https://doi.org/10.1016/j.arr.2016.03.008

Cholesterol plays a vital role in the human body as a precursor of steroid hormones and bile acids, in addition to providing structure to cell membranes. Whole body cholesterol metabolism is maintained by a highly coordinated balancing act between ch... Read More about Cholesterol metabolism: A review of how ageing disrupts the biological mechanisms responsible for its regulation.

Aging and computational systems biology (2016)
Journal Article
Mooney, K. M., Morgan, A. E., & Mc Auley, M. T. (2016). Aging and computational systems biology. Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 8(2), 123-139. https://doi.org/10.1002/wsbm.1328

Aging research is undergoing a paradigm shift, which has led to new and innovative methods of exploring this complex phenomenon. The systems biology approach endeavors to understand biological systems in a holistic manner, by taking account of intrin... Read More about Aging and computational systems biology.

The synergistic effect of gentamicin and ceftazidime against Pseudomonas fluorescens (2014)
Journal Article
Morgan, A. E. (2014). The synergistic effect of gentamicin and ceftazidime against Pseudomonas fluorescens. Bioscience Horizons, 7, hzu007-hzu007. https://doi.org/10.1093/biohorizons/hzu007

With antibiotic resistance becoming a significant problem in recent years, methodologies to overcome resistance have quickly become a necessity. One such mechanism to overcome resistance is to use antibiotics in combination. Clinical advice recommend... Read More about The synergistic effect of gentamicin and ceftazidime against Pseudomonas fluorescens.