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Development of NanoLuc-PEST expressing Leishmania mexicana as a new drug discovery tool for axenic- and intramacrophage-based assays (2018)
Journal Article
Berry, S., Hameed, H., Thomason, A., Maciej-Hulme, M., Saif Abou-Akkada, S., Horrocks, P., & Price, H. (2018). Development of NanoLuc-PEST expressing Leishmania mexicana as a new drug discovery tool for axenic- and intramacrophage-based assays. PLoS Neglected Tropical Diseases, 12(7), e0006639. https://doi.org/10.1371/journal.pntd.0006639

The protozoan parasite Leishmania causes leishmaniasis; a spectrum of diseases of which there are an estimated 1 million new cases each year. Current treatments are toxic, expensive, difficult to administer, and resistance to them is emerging. New th... Read More about Development of NanoLuc-PEST expressing Leishmania mexicana as a new drug discovery tool for axenic- and intramacrophage-based assays.

Half the story : thermal effects on within-host infectious disease progression in a warming climate (2017)
Journal Article
Stewart, A., Hablutzel, P., Brown, M., Watson, H., Parker-Norman, S., Tober, A., …Jackson, J. (2018). Half the story : thermal effects on within-host infectious disease progression in a warming climate. Global Change Biology, 24(1), 371-386. https://doi.org/10.1111/gcb.13842

Immune defence is temperature-dependent in cold-blooded vertebrates (CBVs) and thus directly impacted by global warming. We asked whether immunity and within-host infectious disease progression are altered in CBVs under realistic climate warming in a... Read More about Half the story : thermal effects on within-host infectious disease progression in a warming climate.

Seasonal immunoregulation in a naturally occurring vertebrate (2016)
Journal Article
vertebrate. BMC Genomics, 17(369), https://doi.org/10.1186/s12864-016-2701-7

Background: Fishes show seasonal patterns of immunity, but such phenomena are imperfectly understood in vertebrates generally, even in humans and mice. As these seasonal patterns may link to infectious disease risk and individual condition, the nat... Read More about Seasonal immunoregulation in a naturally occurring vertebrate.