p73 and caspase-cleaved p73 fragments localize to mitochondria and augment TRAIL-induced apoptosis
(2008)
Journal Article
Sayan, A., Sayan, B., Gogvadze, V., Dinsdale, G., Nyman, U., Hansen, T., …Melino, G. (2008). p73 and caspase-cleaved p73 fragments localize to mitochondria and augment TRAIL-induced apoptosis. Oncogene, 27, 4363-4372. https://doi.org/10.1038/onc.2008.64
The p73 protein, a member of the p53 family, has both developmental and tumorigenic functions. Here we show that p73 is cleaved by caspase-3 and -8 both in vitro and in vivo during apoptosis elicited by DNA-damaging drugs and tumor necrosis factor-re... Read More about p73 and caspase-cleaved p73 fragments localize to mitochondria and augment TRAIL-induced apoptosis.