All Outputs (5)

PIR2/Rnf144B regulates epithelial homeostasis by mediating degradation of p21 WAF1 and p63 (2012)
Journal Article
Conforti, F., Yang, A., Piro, M., Mellone, M., Terrinoni, A., Candi, E., …Sayan, B. (2012). PIR2/Rnf144B regulates epithelial homeostasis by mediating degradation of p21 WAF1 and p63. Oncogene, 32, https://doi.org/10.1038/onc.2012.497

ΔNp63 is a transcription factor that is critical for the development of stratified epithelia and is overexpressed or amplified in >80% of squamous cell carcinomas (SCCs). We identified the RING finger E3 ubiquitin ligase PIR2/Rnf144b as a direct tran... Read More about PIR2/Rnf144B regulates epithelial homeostasis by mediating degradation of p21 WAF1 and p63.

Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer (2012)
Journal Article
Tucci, P., Agostini, M., Grespi, F., Merkert, E., Terrinoni, A., Vousden, K., …Sayan, B. (2012). Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer. Proceedings of the National Academy of Sciences, 109(38), https://doi.org/10.1073/pnas.1110977109

p63 inhibits metastasis. Here, we show that p63 (both TAp63 and ΔNp63 isoforms) regulates expression of miR-205 in prostate cancer (PCa) cells, and miR-205 is essential for the inhibitory effects of p63 on markers of epithelial–mesenchymal transition... Read More about Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer.

Apoptin induces apoptosis by changing the equilibrium between the stability of TAp73 and DNp73 isoforms through ubiquitin ligase PIR2 (2012)
Journal Article
Taebunpakul, P., Sayan, B., Flinterman, M., Klanrit, P., Gaken, J., Odell, E., …Tavassoli, M. (2012). Apoptin induces apoptosis by changing the equilibrium between the stability of TAp73 and DNp73 isoforms through ubiquitin ligase PIR2. Apoptosis, 17, https://doi.org/10.1007/s10495-012-0720-7

Apoptin, a protein derived from the chicken anaemia virus, induces cell death in various cancer cells but shows little or no cytotoxicity in normal cells. The mechanism of apoptin-induced cell death is currently unknown but it appears to induce apopt... Read More about Apoptin induces apoptosis by changing the equilibrium between the stability of TAp73 and DNp73 isoforms through ubiquitin ligase PIR2.

Regulation of p73 activity by post-translational modifications (2012)
Journal Article
Conforti, F., Sayan, A., Sreekamur, R., & Sayan, B. (2012). Regulation of p73 activity by post-translational modifications. Cell Death and Disease, 3, https://doi.org/10.1038/cddis.2012.27

The transcription factor p73 is a member of the p53 family that can be expressed as at least 24 different isoforms with pro- or anti-apoptotic attributes. The TAp73 isoforms are expressed from an upstream promoter and are regarded as bona fide tumor... Read More about Regulation of p73 activity by post-translational modifications.

Relative expression of TAp73 and ΔNp73 isoforms (2012)
Journal Article
Conforti, F., Yang, A., Agostini, M., Rufini, A., Tucci, P., Nicklison-Chirou, M., …Sayan, B. (2012). Relative expression of TAp73 and ΔNp73 isoforms. Aging, 4(3), https://doi.org/10.18632/aging.100441

The transcription factor p73 belongs to the p53 family of tumour suppressors and similar to other family members, transcribed as different isoforms with opposing pro- and anti-apoptotic functions. Unlike p53, p73 mutations are extremely rare in cance... Read More about Relative expression of TAp73 and ΔNp73 isoforms.