All Outputs (2)

Inhibition of Bcl-xL sensitizes cells to mitotic blockers, but not mitotic drivers (2016)
Journal Article
Bennett, A., Sloss, O., Topham, C., Nelson, L., Tighe, A., & Taylor, S. (2016). Inhibition of Bcl-xL sensitizes cells to mitotic blockers, but not mitotic drivers. Open Biology, 6(8), https://doi.org/10.1098/rsob.160134

Cell fate in response to an aberrant mitosis is governed by two competing networks: the spindle assembly checkpoint (SAC) and the intrinsic apoptosis pathway. The mechanistic interplay between these two networks is obscured by functional redundancy a... Read More about Inhibition of Bcl-xL sensitizes cells to mitotic blockers, but not mitotic drivers.

Mcl-1 dynamics influence mitotic slippage and death in mitosis (2016)
Journal Article
Sloss, O., Topham, C., Diez, M., & Taylor, S. (2016). Mcl-1 dynamics influence mitotic slippage and death in mitosis. Oncotarget, 7, 5176-5192. https://doi.org/10.18632/oncotarget.6894

Microtubule-binding drugs such as taxol are frontline treatments for a variety of cancers but exactly how they yield patient benefit is unclear. In cell culture, inhibiting microtubule dynamics prevents spindle assembly, leading to mitotic arrest fol... Read More about Mcl-1 dynamics influence mitotic slippage and death in mitosis.