All Outputs (2)

Novel diarylamides and diarylureas with N-substitution dependent activity against medulloblastoma (2021)
Journal Article
Lawson, C., Ahmed Alta, T., Moschou, G., Skamnaki, V., Solovou, T., Topham, C., …Snape, T. (2021). Novel diarylamides and diarylureas with N-substitution dependent activity against medulloblastoma. European Journal of Medicinal Chemistry, 225, 113751. https://doi.org/10.1016/j.ejmech.2021.113751

Medulloblastoma - highly aggressive and heterogeneous tumours of the cerebellum - account for 15-20% of all childhood brain tumours, and are the most common high-grade childhood embryonal tumour of the central nervous system. Herein, potent in vitro... Read More about Novel diarylamides and diarylureas with N-substitution dependent activity against medulloblastoma.

Exploring potential inhibitors of the HGF-Met signalling pathway as a prospective treatment for paediatric medulloblastoma (2021)
Thesis
Hoyles, N. Exploring potential inhibitors of the HGF-Met signalling pathway as a prospective treatment for paediatric medulloblastoma. (Dissertation). University of Salford

Understanding the function of the HGF-Met signalling axis could present opportunities for new therapeutic treatments for cancer patients. The brain tumour Medulloblastoma is the leading cause of cancer-related death in children and infants meaning re... Read More about Exploring potential inhibitors of the HGF-Met signalling pathway as a prospective treatment for paediatric medulloblastoma.