All Outputs (3)

Validation of a novel ELISA for measurement of MDA-LDL in human plasma (2003)
Journal Article
Bevan, R., Durand, M., Hickenbotham, P., Kitas, G., Patel, P., Podmore, I., …Lunec, J. (2003). Validation of a novel ELISA for measurement of MDA-LDL in human plasma. Free Radical Biology and Medicine, 35(5), 517-527. https://doi.org/10.1016/S0891-5849%2803%2900359-9

The involvement of oxidatively modified low density lipoprotein (LDL) in the development of CHD is widely described. We have produced two antibodies, recognizing the lipid oxidation product malondialdehyde (MDA) on whole LDL or ApoB-100. The antibodi... Read More about Validation of a novel ELISA for measurement of MDA-LDL in human plasma.

Quantification of UVR-induced DNA damage: global- versus gene-specific levels of thymine dimers (2003)
Journal Article
Karakoula, A., Evans, M., Podmore, I., Hutchinson, P., Lunec, J., & Cooke, M. (2003). Quantification of UVR-induced DNA damage: global- versus gene-specific levels of thymine dimers. Journal of Immunological Methods, 277(1-2), 27-37. https://doi.org/10.1016/S0022-1759%2803%2900122-4

The induction and repair of DNA damage has been shown to occur heterogeneously throughout the mammalian genome. As a consequence, analysis of these parameters at a global genome level may not reflect important gene-level events. Few techniques have b... Read More about Quantification of UVR-induced DNA damage: global- versus gene-specific levels of thymine dimers.

Novel monoclonal antibody recognition of oxidative DNA damage adduct, deoxycytidine-glyoxal (2003)
Journal Article
Mistry, N., Podmore, I., Cooke, M., Butler, P., Griffiths, H., Herbert, K., & Lunec, J. (2003). Novel monoclonal antibody recognition of oxidative DNA damage adduct, deoxycytidine-glyoxal. Laboratory Investigation, 83(2), 241-250. https://doi.org/10.1097/01.LAB0000053915.88556.ED

Glyoxal, a reactive aldehyde, is a decomposition product of lipid hydroperoxides, oxidative deoxyribose breakdown, or autoxidation of sugars, such as glucose. It readily forms DNA adducts, generating potential carcinogens such as glyoxalated deoxycyt... Read More about Novel monoclonal antibody recognition of oxidative DNA damage adduct, deoxycytidine-glyoxal.