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All Outputs (3)

Synthesis of small-molecule HGF-Met inhibitors for use in preventing cell motility (2020)
Thesis
Bunte, A. Synthesis of small-molecule HGF-Met inhibitors for use in preventing cell motility. (Dissertation). University of Salford

Glycosaminoglycans are becoming more and more focused upon as a research topic due to the broad use they have in aiding wound healing and preventing cell motility through competitive inhibition of the HGF-Met pathway. This pathway is extremely import... Read More about Synthesis of small-molecule HGF-Met inhibitors for use in preventing cell motility.

Lead optimisation of dehydroemetine for repositioned use in malaria (2020)
Journal Article
Panwar, P., Burusco, K., Abubaker, M., Matthews, H., Gutnov, A., Fernández-Álvaro, E., …Nirmalan, N. (2020). Lead optimisation of dehydroemetine for repositioned use in malaria. Antimicrobial Agents and Chemotherapy, 64(4), 1-10. https://doi.org/10.1128/AAC.01444-19

Drug repositioning offers an effective alternative to de novo drug design to tackle the urgent need for novel anti-malarial treatments. The anti-amoebic compound, emetine dihydrochloride, has been identified as a potent in-vitro inhibitor of the mult... Read More about Lead optimisation of dehydroemetine for repositioned use in malaria.

Investigating the anti-proliferative properties and their mechanism(s) of action of marine derived glycosaminoglycans from two marine sources (2020)
Thesis
two marine sources. (Dissertation). University of Salford

The purpose of this study was to investigate the chemotherapeutic properties of marine derived glycosaminoglycans (GAGs) and investigate their mechanism(s) of action. The secondary purpose was to investigate differences between the already studied co... Read More about Investigating the anti-proliferative properties and their mechanism(s) of action of marine derived glycosaminoglycans from two marine sources.