All Outputs (8)

A deterministic oscillatory model of microtubule growth and shrinkage for differential actions of short chain fatty acids (2016)
Journal Article

Short chain fatty acids (SCFA), principally acetate, propionate, butyrate and valerate, are produced in pharmacologically relevant concentrations by the gut microbiome. Investigations indicate that they exert beneficial effects on colon epithelia. Th... Read More about A deterministic oscillatory model of microtubule growth and shrinkage for differential actions of short chain fatty acids.

A mathematical model of microbial folate biosynthesis and utilisation: implications for antifolate development (2016)
Journal Article

The metabolic biochemistry of folate biosynthesis and utilisation has evolved into a complex network of reactions. Although this complexity represents challenges to the field of folate research it has also provided a renewed source for antimetabolite... Read More about A mathematical model of microbial folate biosynthesis and utilisation: implications for antifolate development.

Computational modelling folate metabolism and DNA methylation: implications for understanding health and ageing (2016)
Journal Article

Dietary folates have a key role to play in health, as deficiencies in the intake of these B vitamins have been implicated in a wide variety of clinical conditions. The reason for this is folates function as single carbon donors in the synthesis of me... Read More about Computational modelling folate metabolism and DNA methylation: implications for understanding health and ageing.

Investigating cholesterol metabolism and ageing using a systems biology approach (2016)
Journal Article
Morgan, A. E., Mooney, K. M., Wilkinson, S. J., Pickles, N. A., & Mc Auley, M. T. (2017). Investigating cholesterol metabolism and ageing using a systems biology approach. Proceedings of the Nutrition Society, 76(3), 378-391. https://doi.org/10.1017/S0029665116002822

CVD accounted for 27 % of all deaths in the UK in 2014, and was responsible for 1·7 million hospital admissions in 2013/2014. This condition becomes increasingly prevalent with age, affecting 34·1 and 29·8 % of males and females over 75 years of age... Read More about Investigating cholesterol metabolism and ageing using a systems biology approach.

Obesity and the dysregulation of fatty acid metabolism: implications for healthy aging (2016)
Journal Article
Morgan, A., Mooney, K., & Mc Auley, M. (2016). Obesity and the dysregulation of fatty acid metabolism: implications for healthy aging. Expert Review of Endocrinology and Metabolism, 11(6), 501-510. https://doi.org/10.1080/17446651.2016.1245141

Introduction: The population of the world is aging. In 2010, an estimated 524 million people were aged 65 years or older representing eight percent of the global population. By 2050, this number is expected to nearly triple to approximately 1.5 billi... Read More about Obesity and the dysregulation of fatty acid metabolism: implications for healthy aging.

Mathematically modelling the dynamics of cholesterol metabolism and ageing (2016)
Journal Article
Morgan, A., Mooney, K., Wilkinson, S., Pickles, N., & Mc Auley, M. (2016). Mathematically modelling the dynamics of cholesterol metabolism and ageing. BioSystems, 145, 19-32. https://doi.org/10.1016/j.biosystems.2016.05.001

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the UK. This condition becomes increasingly prevalent during ageing; 34.1% and 29.8% of males and females respectively, over 75 years of age have an underlying cardiovasc... Read More about Mathematically modelling the dynamics of cholesterol metabolism and ageing.

Cholesterol metabolism: A review of how ageing disrupts the biological mechanisms responsible for its regulation (2016)
Journal Article
Morgan, A., Mooney, K., Wilkinson, S., Pickles, N., & Mc Auley, M. (2016). Cholesterol metabolism: A review of how ageing disrupts the biological mechanisms responsible for its regulation. Ageing research reviews, 27, 108-124. https://doi.org/10.1016/j.arr.2016.03.008

Cholesterol plays a vital role in the human body as a precursor of steroid hormones and bile acids, in addition to providing structure to cell membranes. Whole body cholesterol metabolism is maintained by a highly coordinated balancing act between ch... Read More about Cholesterol metabolism: A review of how ageing disrupts the biological mechanisms responsible for its regulation.

Aging and computational systems biology (2016)
Journal Article
Mooney, K. M., Morgan, A. E., & Mc Auley, M. T. (2016). Aging and computational systems biology. Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 8(2), 123-139. https://doi.org/10.1002/wsbm.1328

Aging research is undergoing a paradigm shift, which has led to new and innovative methods of exploring this complex phenomenon. The systems biology approach endeavors to understand biological systems in a holistic manner, by taking account of intrin... Read More about Aging and computational systems biology.