All Outputs (26)

Antimicrobial resistance and virulence of Klebsiella pneumoniae isolates from Palestinian hospitals (2025)
Thesis

Antimicrobial resistance (AMR) is an urgent global health challenge today, severely impacting regions facing issues like healthcare crises and conflict, such as Palestine. This study investigated the antibiotic susceptibility of 121 Klebsiella pneumo... Read More about Antimicrobial resistance and virulence of Klebsiella pneumoniae isolates from Palestinian hospitals.

A product of skin microbiota improves hallmarks of wound healing in diabetes mellitus: an in vitro investigation (2025)
Thesis

Diabetes mellitus is a critical global health disease characterised by persistent hyperglycaemia, which leads to various complications. Poor wound healing and diabetic foot ulcers are the two main complications of this disease. Lysates and cellfree s... Read More about A product of skin microbiota improves hallmarks of wound healing in diabetes mellitus: an in vitro investigation.

Do plasma cytokine levels correlate to cardiac function in coronary artery disease? (2024)
Presentation / Conference Contribution

Coronary artery disease (CAD) affects over 20 million people worldwide and is the leading cause of morbidity and mortality.1 In CAD, atherosclerosis narrows the coronary arteries leading to myocardial ischemia thence decreased systolic and diastolic... Read More about Do plasma cytokine levels correlate to cardiac function in coronary artery disease?.

The Role of Tumour Necrosis Factor-α in Coronary Artery Disease (2024)
Thesis

Coronary artery disease (CAD) is a chronic inflammatory condition associated with high rates
of mortality worldwide. Pro-inflammatory cytokines such as tumour necrosis factor (TNFα)
play a key role in CAD pathogenesis, though the degree to which TN... Read More about The Role of Tumour Necrosis Factor-α in Coronary Artery Disease.

Perivascular adipose tissue anticontractile function is mediated by both endothelial and neuronal nitric oxide synthase isoforms. (2022)
Journal Article
Saxton, S., Withers, S., & Heagerty, A. (2022). Perivascular adipose tissue anticontractile function is mediated by both endothelial and neuronal nitric oxide synthase isoforms. Journal of Vascular Research, 59(5), 1-15. https://doi.org/10.1159/000526027

The mechanism of the perivascular adipose tissue (PVAT) anticontractile effect is well characterized in rodent visceral vascular beds; however, little is known about the mechanism of PVAT anticontractile function in subcutaneous vessels. In addition,... Read More about Perivascular adipose tissue anticontractile function is mediated by both endothelial and neuronal nitric oxide synthase isoforms..

Investigating the effect of prophylactic D-mannose treatment on adhesion of Uropathogenic Escherichia coli to the human bladder epithelium (2022)
Thesis

Urinary tract infection (UTI) is the second most common bacterial infection worldwide, affecting millions of people annually, mainly women, and primarily caused by Uropathogenic Escherichia coli (UPEC). Treatment of UTIs is challenged by the continue... Read More about Investigating the effect of prophylactic D-mannose treatment on adhesion of Uropathogenic Escherichia coli to the human bladder epithelium.

Characterisation of cardiac cellular and vascular function in Ischemic heart disease (2021)
Thesis

Ischemic heart disease (IHD) is the most common cause of death across the globe, of which global
mortality rates are projected to continue rising into the future. Therapies used to treat the most
chronic cases of IHD are focused on the revascularis... Read More about Characterisation of cardiac cellular and vascular function in Ischemic heart disease.

Exploring the influence of adipokines on neuronal function in Alzheimer’s disease (2021)
Thesis

Alzheimer’s disease (AD) is one of the major causes of dementia. Alzheimer’s disease is an irreversible, slow neurodegenerative disease leading to memory and language impairment and amyloid-β plaques and intraneuronal neurofibrillary tangles are the... Read More about Exploring the influence of adipokines on neuronal function in Alzheimer’s disease.

Restoring perivascular adipose tissue function in obesity using exercise (2021)
Journal Article
Saxton, S., Toms, L., Aldous, R., Withers, S., Ohanian, J., & Heagerty, A. (2021). Restoring perivascular adipose tissue function in obesity using exercise. Cardiovascular Drugs and Therapy, 35(6), 1291-1304. https://doi.org/10.1007/s10557-020-07136-0

Perivascular adipose tissue (PVAT) exerts an anti-contractile effect which is vital in regulating vascular tone. This effect is mediated via sympathetic nervous stimulation of PVAT by a mechanism which involves noradrenaline uptake through organic ca... Read More about Restoring perivascular adipose tissue function in obesity using exercise.

Proinflammatory cytokines as mediators of phenotypic change in bacteria implicated in ventilator-associated pneumonia (2021)
Thesis

Ventilator-associated pneumonia (VAP) is a common hospital-acquired infection in intensive care. VAP is associated with increased hospital stay, healthcare costs, and high mortality. VAP is difficult to diagnose and manage appropriately, leading to w... Read More about Proinflammatory cytokines as mediators of phenotypic change in bacteria implicated in ventilator-associated pneumonia.

Interleukin-33 rescues perivascular adipose tissue anticontractile function in obesity (2020)
Journal Article

Perivascular adipose tissue (PVAT) depots are metabolically active and play a major vasodilator role in healthy lean individuals. In obesity, they become inflamed and eosinophil-depleted and the anticontractile function is lost with the development o... Read More about Interleukin-33 rescues perivascular adipose tissue anticontractile function in obesity.

Perivascular adipose tissue - an immune cell metropolis (2020)
Journal Article
Saxton, S., Heagerty, A., & Withers, S. (2020). Perivascular adipose tissue - an immune cell metropolis. Experimental Physiology, 105(9), 1440-1443. https://doi.org/10.1113/EP087872

What is the topic of this review? The review discusses how eosinophils can contribute to the function of perivascular adipose tissue and explores the mechanisms involved. What advances does it highlight? Understanding the communication between the ce... Read More about Perivascular adipose tissue - an immune cell metropolis.

MiRNAs as novel adipokines : obesity-related circulating MiRNAs influence chemosensitivity in cancer patients (2020)
Journal Article
Withers, S., Dewhurst, T., Hammond, C., & Topham, C. (2020). MiRNAs as novel adipokines : obesity-related circulating MiRNAs influence chemosensitivity in cancer patients. Non-Coding RNA, 6(1), e5. https://doi.org/10.3390/ncrna6010005

Adipose tissue is an endocrine organ, capable of regulating distant physiological processes in other tissues via the release of adipokines into the bloodstream. Recently, circulating adipose-derived microRNAs (miRNAs) have been proposed as a novel cl... Read More about MiRNAs as novel adipokines : obesity-related circulating MiRNAs influence chemosensitivity in cancer patients.

Mechanisms of medulloblastoma vulnerability and new targeted therapies (2020)
Thesis

Medulloblastoma (MB) is the most common malignant paediatric brain tumour accounting for about 20% of all childhood brain cancers. Over the last decade, a consensus has been reached over the existence of 4 main molecular subtypes, known as WNT-activa... Read More about Mechanisms of medulloblastoma vulnerability and new targeted therapies.

P735 Interleukin-33 induced eosinophilia restores perivascular adipose tissue function in obesity (2019)
Journal Article

Abstract Background/Purpose Perivascular adipose tissue (PVAT) is essential in the modulation of vascular tone. Recently we have shown that resident eosinophils play a vital role in regulating PVAT function. In obesity, eosinophil numbers are reduced... Read More about P735 Interleukin-33 induced eosinophilia restores perivascular adipose tissue function in obesity.

Perivascular adipose tissue contributes to the modulation of vascular tone in vivo (2019)
Journal Article
Saxton, S., Withers, S., Nyvad, J., Mazur, A., Matchkov, V., Heagerty, A., & Aalkjær, C. (2019). Perivascular adipose tissue contributes to the modulation of vascular tone in vivo. Journal of Vascular Research, 56(6), 320-332. https://doi.org/10.1159/000502689

Perivascular adipose tissue (PVAT) reduces vascular tone in isolated arteries in vitro, however there are no studies of PVAT effects on vascular tone in vivo. In vitro adipocyte β3-adrenoceptors play a role in PVAT function via secretion of the vasod... Read More about Perivascular adipose tissue contributes to the modulation of vascular tone in vivo.

Mechanistic links between obesity, diabetes, and blood pressure : role of perivascular adipose tissue (2019)
Journal Article
Saxton, S., Clark, B., Withers, S., Eringa, E., & Heagerty, A. (2019). Mechanistic links between obesity, diabetes, and blood pressure : role of perivascular adipose tissue. Physiological Reviews, 99(4), 1701-1763. https://doi.org/10.1152/physrev.00034.2018

Obesity is increasingly prevalent and is associated with substantial cardiovascular risk. Adipose tissue distribution and morphology play a key role in determining the degree of adverse effects, and a key factor in the disease process appears to be t... Read More about Mechanistic links between obesity, diabetes, and blood pressure : role of perivascular adipose tissue.

Towards a clinically relevant model for investigation of host-microbe interactions in ventilator-associated pneumonia (2019)
Journal Article

Ventilator-associated pneumonia (VAP) is amongst the most common healthcare-associated infections worldwide. Current understanding of the underlying mechanisms has focussed on either the microbiological or physiological elements but host-microbe inte... Read More about Towards a clinically relevant model for investigation of host-microbe interactions in ventilator-associated pneumonia.

Emerging roles of sympathetic nerves and inflammation in perivascular adipose tissue (2019)
Journal Article
Saxton, S., Withers, S., & Heagerty, A. (2019). Emerging roles of sympathetic nerves and inflammation in perivascular adipose tissue. Cardiovascular Drugs and Therapy, 33(2), 245-259. https://doi.org/10.1007/s10557-019-06862-4

Perivascular adipose tissue (PVAT) is no longer recognised as simply a structural support for the vasculature, and we now know that PVAT releases vasoactive factors which modulate vascular function. Since the discovery of this function in 1991, PVAT... Read More about Emerging roles of sympathetic nerves and inflammation in perivascular adipose tissue.

β3-adrenoceptor stimulation of perivascular adipocytes leads to increased fat cell-derived nitric oxide and vascular relaxation in small arteries (2018)
Journal Article
Bussey, C., Withers, S., Saxton, S., Bodagh, N., Aldous, R., & Heagerty, A. (2018). β3-adrenoceptor stimulation of perivascular adipocytes leads to increased fat cell-derived nitric oxide and vascular relaxation in small arteries. British Journal of Pharmacology, 175(18), 2685-3698. https://doi.org/10.1111/bph.14433

BACKGROUND AND PURPOSE
In response to norepinephrine healthy perivascular adipose tissue (PVAT) exerts an anticontractile effect on adjacent small arterial tissue. Organ bath solution transfer experiments have demonstrated the release of PVAT-deriv... Read More about β3-adrenoceptor stimulation of perivascular adipocytes leads to increased fat cell-derived nitric oxide and vascular relaxation in small arteries.