All Outputs (12941)

Two-Photon Microscopy of E-Combretastatin uptake and activation in live mammalian cells
Thesis

Cancer is one of the most common causes of death in the Western world. Hence, the
development of novel effective treatment modalities to combat this disease is important.
Combretastatins are powerful anticancer drugs that are being evaluated in pha... Read More about Two-Photon Microscopy of E-Combretastatin uptake and activation in live mammalian cells.

Capacity building for post disaster waste management : construction and demolition waste
Thesis

Though increasing nature of impacts from disasters has made post disaster management a
significant area of concern, management of disaster waste is identified as an area of least
concern. It presents momentous challenges for those with inadequate c... Read More about Capacity building for post disaster waste management : construction and demolition waste.

Autologous intestinal lengthening procedures for short bowel syndrome. A systematic review of clinical effectiveness and an assessment of their utility for adult and paediatric patients with intestinal failure in the UK
Thesis

Introduction:
Short bowel syndrome (SBS) results from surgical resection, congenital defect
or disease-associated loss of absorption and is characterized by the inability
to maintain protein-energy, fluid, electrolyte or micronutrient balances whe... Read More about Autologous intestinal lengthening procedures for short bowel syndrome. A systematic review of clinical effectiveness and an assessment of their utility for adult and paediatric patients with intestinal failure in the UK.

Using virtual reality to evaluate how people might feel and perform within adaptive architecture
Thesis

With the rapid development of interactive building materials that can react in real time, a
new type of architecture is about to emerge. Buildings that can transform their selves and
change their appearance are gaining popularity and could become t... Read More about Using virtual reality to evaluate how people might feel and perform within adaptive architecture.

The role of public private partnership in highway infrastructure development and sustainability in Nigeria
Thesis

The Nigeria's highway infrastructure are currently being procured and maintained using
the traditional Design, Bid Build (DBB) method. The procurement method and funding
mechanism appeared not to have produced the desired result of timely and cost... Read More about The role of public private partnership in highway infrastructure development and sustainability in Nigeria.

Optical and electronic properties of bismuth-implanted glasses
Journal Article

Photoluminescence (PL) and excitation spectra of Bi melt-doped oxide and chalcogenide glasses are very similar, indicating the same Bi center is present. When implanted with Bi, chalcogenide, phosphate and silica glasses, and BaF2 crystals, all displ... Read More about Optical and electronic properties of bismuth-implanted glasses.

Synthesis and biological evaluation of bisindenoisoquinolines as topoisomerase I inhibitors
Journal Article

The indenoisoquinolines represent a class of non-camptothecin topoisomerase I (Top1) inhibitors that exert cytotoxicity by trapping the covalent complex formed between DNA and Top1 during relaxation of DNA supercoils. As an ongoing evaluation of Top1... Read More about Synthesis and biological evaluation of bisindenoisoquinolines as topoisomerase I inhibitors.

Mainstreaming women in disaster risk reduction in the built environment
Thesis

Natural disasters have long-term implications on sustainable development. They mainly destroy the built environment thereby hindering economic and social development, and causing environment degradation. Mainstreaming disaster risk reduction into the... Read More about Mainstreaming women in disaster risk reduction in the built environment.

A critical analysis of the Housing Market Renewal project, with a special focus on the stakeholder power relations and perceived inequalities and discriminatory practices in a private sector regeneration project
Thesis

The context of this study is a Housing Market Renewal project (HMR) in a South Asian lowincome
home-owning community, in a small town in northern England. Its focus is an
investigation into perceived inequalities and discriminatory practices in a p... Read More about A critical analysis of the Housing Market Renewal project, with a special focus on the stakeholder power relations and perceived inequalities and discriminatory practices in a private sector regeneration project.

Towards a format-agnostic approach for production, delivery and rendering of immersive media
Presentation / Conference Contribution

The media industry is currently being pulled in the often-opposing directions of increased realism (high resolution, stereoscopic, large screen) and personalization (selection and control of content, availability on many devices). We investigate the... Read More about Towards a format-agnostic approach for production, delivery and rendering of immersive media.

Electronic table top exercises for major incident training : from pragmatic pilot to multicentre controlled trial
Thesis

Traditional emergency service major incident table top training exercises are presented via ‘low-technology’ means, such as plastic bricks and paper maps, or ‘front-loaded’ via slides presented by an instructor. The purpose of this research was to de... Read More about Electronic table top exercises for major incident training : from pragmatic pilot to multicentre controlled trial.

An empirical study of quality culture in the construction industry : A GCC Context
Thesis

Keywords: Quality, quality culture, construction industry, organisational culture, GCC, construction, critical success factors, strategy, management, leadership, continuity, infrastructure
Quality has proven to be an effective management concept in... Read More about An empirical study of quality culture in the construction industry : A GCC Context.

Managing housing needs in post conflict housing reconstruction
Thesis

Conflicts bring deaths and disabilities, population displacements, destruction of properties and changes to societies. Conflicts also devastate the economy, health, education and institutions. Within this context post conflict reconstruction contrib... Read More about Managing housing needs in post conflict housing reconstruction.

Assessing doses to terrestrial wildlife at a radioactive waste disposal site: Inter-comparison of modelling approaches
Journal Article

Radiological doses to terrestrial wildlife were examined in this model inter-comparison study that emphasised factors causing variability in dose estimation. The study participants used varying modelling approaches and information sources to estimate... Read More about Assessing doses to terrestrial wildlife at a radioactive waste disposal site: Inter-comparison of modelling approaches.

HIV protease inhibitors are substrates for OATP1A2, OATP1B1 and OATP1B3 and lopinavir plasma concentrations are influenced by SLCO1B1 polymorphisms
Journal Article

OBJECTIVE: OATP1B1 and OATP1B3 are major hepatic drug transporters whilst OATP1A2 is mainly located in the brain but is also located in liver and several other organs. These transporters affect the distribution and clearance of many endobiotics and x... Read More about HIV protease inhibitors are substrates for OATP1A2, OATP1B1 and OATP1B3 and lopinavir plasma concentrations are influenced by SLCO1B1 polymorphisms.

Nanoscale characterization and magnetic property of NiCoCu/Cu multilayer nanowires
Journal Article

NiCo/Cu multilayer nanowires have been successfully fabricated by a pulse electrodeposition technique using anodic aluminum oxide templates, and their chemistry, crystal structure and
magnetic properties characterized at the nanoscale. It was found... Read More about Nanoscale characterization and magnetic property of NiCoCu/Cu multilayer nanowires.

Three-dimensional imaging of magnetic domains
Journal Article

Magnetic domains have been the subject of much scientific investigation since their theoretical
existence was first postulated by P.-E. Weiss over a century ago. Up to now, the threedimensional
(3D) domain structure of bulk magnets has never been o... Read More about Three-dimensional imaging of magnetic domains.

BeReal – A benefits realisation process from planning to delivery: effective benefits realisation
Book

Delivering sustainable reform within an ever changing
external environment, usually reliant on a range of
stakeholders stakeholders, requires a different way of thinking, a
better understanding of the drivers of benefits realisation
and more effe... Read More about BeReal – A benefits realisation process from planning to delivery: effective benefits realisation.

An MVA-based vaccine targeting the oncofetal antigen 5T4 in patients undergoing surgical resection of colorectal cancer liver metastases
Journal Article

We investigated the use of a therapeutic vaccine, TroVax in patients undergoing surgical resection of colorectal cancer liver metastases. Systemic immunity generated by vaccination before and after resection of metastases was measured in addition to... Read More about An MVA-based vaccine targeting the oncofetal antigen 5T4 in patients undergoing surgical resection of colorectal cancer liver metastases.

London’s hydrogen economy: negotiating the ‘global’, the ‘regional’ and the ‘local’
Preprint / Working Paper