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All Outputs (5)

Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact (2020)
Journal Article

Spaceflight is known to impose changes on human physiology with unknown molecular etiologies. To reveal these causes, we used a multi-omics, systems biology analytical approach using biomedical profiles from fifty-nine astronauts and data from NASA's... Read More about Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact.

PALMER: improving pathway annotation based on the biomedical literature mining with a constrained latent block model (2020)
Journal Article
Nam, J. H., Couch, D., da Silveira, W. A., Yu, Z., & Chung, D. (2020). PALMER: improving pathway annotation based on the biomedical literature mining with a constrained latent block model. BMC Bioinformatics, 21, Article 432. https://doi.org/10.1186/s12859-020-03756-3

Background: In systems biology, it is of great interest to identify previously unreported associations between genes. Recently, biomedical literature has been considered as a valuable resource for this purpose. While classical clustering algorithms h... Read More about PALMER: improving pathway annotation based on the biomedical literature mining with a constrained latent block model.

Prominence of IL6, IGF, TLR, and Bioenergetics Pathway Perturbation in Lung Tissues of Scleroderma Patients With Pulmonary Fibrosis (2020)
Journal Article
Renaud, L., Abraham da Silveira, W., Takamura, N., Hardiman, G., & Feghali-Bostwick, C. (2020). Prominence of IL6, IGF, TLR, and Bioenergetics Pathway Perturbation in Lung Tissues of Scleroderma Patients With Pulmonary Fibrosis. Frontiers in Immunology, 11, Article 383. https://doi.org/10.3389/fimmu.2020.00383

Scleroderma-associated pulmonary fibrosis (SSc-PF) and idiopathic pulmonary fibrosis (IPF) are two of many chronic fibroproliferative diseases that are responsible for nearly 45% of all deaths in developed countries. While sharing several pathobiolog... Read More about Prominence of IL6, IGF, TLR, and Bioenergetics Pathway Perturbation in Lung Tissues of Scleroderma Patients With Pulmonary Fibrosis.