Pharmacoproteomic study of the natural product Ebenfuran III in DU-145 prostate cancer cells: The quantitative and temporal interrogation of chemically induced cell death at the protein level

Roumeltios, T; Halabalaki, M; Alexi, X; Ankrett, D; Giannopoulou, E; Sayan, BS; Skaltsounis, AL

doi:10.1021/pr300968q

All Outputs (3)

p73 regulates serine biosynthesis in cancer (2013)
Journal Article

Activation of serine biosynthesis supports growth and proliferation of cancer cells. Human cancers often exhibit overexpression of phosphoglycerate dehydrogenase (PHGDH), the metabolic enzyme that catalyses the reaction that diverts serine biosynthes... Read More about p73 regulates serine biosynthesis in cancer.

Regulation of myocardial interleukin-6 expression by p53 and STAT1 (2013)
Journal Article
Carroll, C., Sayan, B., Bailey, S., & McCormick, J. (2013). Regulation of myocardial interleukin-6 expression by p53 and STAT1. Journal of Interferon and Cytokine Research, 33(9), https://doi.org/10.1089/jir.2012.0165

Cardiovascular diseases are a major cause of morbidity and mortality worldwide. The interferon inducible transcriptional activator signal transducer and activator of transcription-1 (STAT1) and p53 are two critical transcriptional factors that have p... Read More about Regulation of myocardial interleukin-6 expression by p53 and STAT1.

Pharmacoproteomic study of the natural product Ebenfuran III in DU-145 prostate cancer cells: The quantitative and temporal interrogation of chemically induced cell death at the protein level (2013)
Journal Article
Roumeltios, T., Halabalaki, M., Alexi, X., Ankrett, D., Giannopoulou, E., Sayan, B., & Skaltsounis, A. (2013). Pharmacoproteomic study of the natural product Ebenfuran III in DU-145 prostate cancer cells: The quantitative and temporal interrogation of chemically induced cell death at the protein level. Journal of Proteome Research, 12(4), 1591-1603. https://doi.org/10.1021/pr300968q

A naturally occurring benzofuran derivative, Ebenfuran III (Eb III), was investigated for its antiproliferative effects using the DU-145 prostate cell line. Eb III was isolated from Onobrychis ebenoides of the Leguminosae family, a plant endemic in C... Read More about Pharmacoproteomic study of the natural product Ebenfuran III in DU-145 prostate cancer cells: The quantitative and temporal interrogation of chemically induced cell death at the protein level.