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The transplant rejection response involves neutrophil and macrophage adhesion-mediated trogocytosis and is regulated by NFATc3 (2024)
Journal Article
Zhao, S., Hu, Y., Yang, B., Zhang, L., Xu, M., Jiang, K., …Shen, J. (in press). The transplant rejection response involves neutrophil and macrophage adhesion-mediated trogocytosis and is regulated by NFATc3. Cell Death and Disease, 15(1), 75. https://doi.org/10.1038/s41419-024-06457-4

The anti-foreign tissue (transplant rejection) response, mediated by the immune system, has been the biggest obstacle to successful organ transplantation. There are still many enigmas regarding this process and some aspects of the underlying mechanis... Read More about The transplant rejection response involves neutrophil and macrophage adhesion-mediated trogocytosis and is regulated by NFATc3.

Prevalence of Eimeria Species, Detected by ITS1-PCR Immobilized on FTA Cards, in Future Laying Hens and Breeding Hens in Six Provinces in Northeastern Algeria (2024)
Journal Article
Ayadi, O., Djemai, S., & Hide, G. (2024). Prevalence of Eimeria Species, Detected by ITS1-PCR Immobilized on FTA Cards, in Future Laying Hens and Breeding Hens in Six Provinces in Northeastern Algeria. Acta parasitologica / Witold Stefański Institute of Parasitology, https://doi.org/10.1007/s11686-023-00773-z

Purpose Avian coccidiosis is an important and widely distributed disease that affects global agricultural economies through losses. In Algeria, there is limited epidemiological and ecological knowledge about this disease and this hinders implementat... Read More about Prevalence of Eimeria Species, Detected by ITS1-PCR Immobilized on FTA Cards, in Future Laying Hens and Breeding Hens in Six Provinces in Northeastern Algeria.

Macrophage-mediated trogocytosis contributes to destroying human schistosomes in a non-susceptible rodent host, Microtus fortis (2023)
Journal Article
Shen, J., Zhao, S., Peng, M., Li, Y., Zhang, L., Li, X., …Wu, Z. (in press). Macrophage-mediated trogocytosis contributes to destroying human schistosomes in a non-susceptible rodent host, Microtus fortis. Cell Discovery, 9(1), 101. https://doi.org/10.1038/s41421-023-00603-6

Schistosoma parasites, causing schistosomiasis, exhibit typical host specificity in host preference. Many mammals, including humans, are susceptible to infection, while the widely distributed rodent, Microtus fortis, exhibits natural anti-schistosome... Read More about Macrophage-mediated trogocytosis contributes to destroying human schistosomes in a non-susceptible rodent host, Microtus fortis.

Functional screening reveals Toxoplasma prenylated proteins required for endocytic trafficking and rhoptry protein sorting (2023)
Journal Article
Wang, Q., Sun, M., Tang, T., Lai, D., Liu, J., Maity, S., …Long, S. (2023). Functional screening reveals Toxoplasma prenylated proteins required for endocytic trafficking and rhoptry protein sorting. mBio, https://doi.org/10.1128/mbio.01309-23

In the apicomplexans, endocytosed cargos (e.g., hemoglobin) are trafficked to a specialized organelle for digestion. This follows a unique endocytotic process at the micropore/cytostome in these parasites. However, the mechanism underlying endocytic... Read More about Functional screening reveals Toxoplasma prenylated proteins required for endocytic trafficking and rhoptry protein sorting.

The Toxoplasma monocarboxylate transporters are involved in the metabolism within the apicoplast and are linked to parasite survival (2023)
Journal Article
Dong, H., He, K., Yang, J., Zheng, W., Lai, D., Liu, J., …Long, S. (2024). The Toxoplasma monocarboxylate transporters are involved in the metabolism within the apicoplast and are linked to parasite survival. eLife, 12, RP88866. https://doi.org/10.7554/elife.88866.3

The apicoplast is a four-membrane plastid found in the apicomplexans, which harbors biosynthesis and organelle housekeeping activities in the matrix. However, the mechanism driving the flux of metabolites, in and out, remains unknown. Here, we used T... Read More about The Toxoplasma monocarboxylate transporters are involved in the metabolism within the apicoplast and are linked to parasite survival.

The Toxoplasma micropore mediates endocytosis for selective nutrient salvage from host cell compartments (2023)
Journal Article
Wan, W., Dong, H., Lai, D., Yang, J., He, K., Tang, X., …Long, S. (in press). The Toxoplasma micropore mediates endocytosis for selective nutrient salvage from host cell compartments. Nature communications, 14(1), 997. https://doi.org/10.1038/s41467-023-36571-4

Apicomplexan parasite growth and replication relies on nutrient acquisition from host cells, in which intracellular multiplication occurs, yet the mechanisms that underlie the nutrient salvage remain elusive. Numerous ultrastructural studies have doc... Read More about The Toxoplasma micropore mediates endocytosis for selective nutrient salvage from host cell compartments.

Investigation into the potential of using UV-treated sporulated oocysts of Eimeria tenella as a local solution to immunization of chickens against caecal coccidiosis (2023)
Journal Article
Djemai, S., Mekroud, A., Hide, G., Khelifi, D., & Bellil, I. (in press). Investigation into the potential of using UV-treated sporulated oocysts of Eimeria tenella as a local solution to immunization of chickens against caecal coccidiosis. Journal of Parasitic Diseases, https://doi.org/10.1007/s12639-022-01562-7

In this study, we aim to evaluate the immune response of chickens to UV-treated sporulated oocysts as a means of protection against caecal coccidiosis caused by field strains of Eimeria tenella. Two groups of chicks were immunized using prepared UV-t... Read More about Investigation into the potential of using UV-treated sporulated oocysts of Eimeria tenella as a local solution to immunization of chickens against caecal coccidiosis.

PAG3 promotes the differentiation of bloodstream forms in Trypanosoma brucei and reveals the evolutionary relationship among the Trypanozoon trypanosomes (2022)
Journal Article
Wen, Y., Tang, H., Cai, X., Wu, N., Xu, J., Su, B., …Lai, D. (2022). PAG3 promotes the differentiation of bloodstream forms in Trypanosoma brucei and reveals the evolutionary relationship among the Trypanozoon trypanosomes. Frontiers in Cellular and Infection Microbiology, 12, https://doi.org/10.3389/fcimb.2022.1021332

Introduction: Trypanosoma brucei, T. evansi and T. equiperdum are members of the subgenus Trypanozoon and are highly similar morphologically and genetically. The main differences between these three species are their differentiation patterns in the h... Read More about PAG3 promotes the differentiation of bloodstream forms in Trypanosoma brucei and reveals the evolutionary relationship among the Trypanozoon trypanosomes.

Prevalence of Eimeria species, detected by ITS1-PCR, in broiler poultry farms located in seven provinces of northeastern Algeria. (2022)
Journal Article
Djemai, S., Ayadi, O., Khelifi, D., Bellil, I., & Hide, G. (2022). Prevalence of Eimeria species, detected by ITS1-PCR, in broiler poultry farms located in seven provinces of northeastern Algeria. Tropical Animal Health and Production, 54(5), 250. https://doi.org/10.1007/s11250-022-03252-1

Coccidiosis is an important global chickens' disease which can cause serious economic losses in the poultry industry worldwide. Little is known about the extent of infection or diversity, of the causative agent Eimeria spp., in Algeria. A priority, t... Read More about Prevalence of Eimeria species, detected by ITS1-PCR, in broiler poultry farms located in seven provinces of northeastern Algeria..

Novel insertions in the mitochondrial maxicircle of Trypanosoma musculi, a mouse trypanosome (2022)
Journal Article
Wang, J., Lin, R., Zhang, X., Hide, G., Lun, Z., & Lai, D. (2022). Novel insertions in the mitochondrial maxicircle of Trypanosoma musculi, a mouse trypanosome. Parasitology, 1-42. https://doi.org/10.1017/S0031182022001019

Trypanosoma musculi is a, globally distributed, mouse-specific haemoflagellate, of the family Trypanosomatidae, which shares similar characteristics in morphology with Trypanosoma lewisi. The kinetoplast (mitochondrial) DNA of Trypanosomatidae flagel... Read More about Novel insertions in the mitochondrial maxicircle of Trypanosoma musculi, a mouse trypanosome.

Nile tilapia (Oreochromis niloticus) can be experimentally infected with both marine and freshwater fish trypanosomes. (2022)
Journal Article
Chen, K., Zhang, P., Yang, T., Wen, Y., Hide, G., Lun, Z., & Lai, D. (2022). Nile tilapia (Oreochromis niloticus) can be experimentally infected with both marine and freshwater fish trypanosomes. Experimental Parasitology, 239, 108288. https://doi.org/10.1016/j.exppara.2022.108288

Trypanosomes are haemoflagellates found in vertebrate species and many of them can cause death in infected hosts including fish and humans. With the development of high-density farming in marine and freshwater fish aquaculture systems, severe disease... Read More about Nile tilapia (Oreochromis niloticus) can be experimentally infected with both marine and freshwater fish trypanosomes..

iNOS is essential to maintain a protective Th1/Th2 response and the production of cytokines/chemokines against Schistosoma japonicum infection in rats (2022)
Journal Article
Shen, J., Yu, S., Peng, M., Lai, D., Hide, G., Wu, Z., & Lun, Z. (2022). iNOS is essential to maintain a protective Th1/Th2 response and the production of cytokines/chemokines against Schistosoma japonicum infection in rats. PLoS Neglected Tropical Diseases, 16(5), e0010403. https://doi.org/10.1371/journal.pntd.0010403

Humans and a wide range of mammals are generally susceptible to Schistosoma infection, while some rodents such as Rattus rats and Microtus spp are not. We previously demonstrated that inherent high expression levels of nitric oxide (NO), produced by... Read More about iNOS is essential to maintain a protective Th1/Th2 response and the production of cytokines/chemokines against Schistosoma japonicum infection in rats.

Transplantation of Gut Microbiota From High-Fat-Diet-Tolerant Cynomolgus Monkeys Alleviates Hyperlipidemia and Hepatic Steatosis in Rats. (2022)
Journal Article
Gao, J., Rao, J., Wei, Z., Xia, S., Huang, L., Tang, M., …Chen, J. (2022). Transplantation of Gut Microbiota From High-Fat-Diet-Tolerant Cynomolgus Monkeys Alleviates Hyperlipidemia and Hepatic Steatosis in Rats. Frontiers in Microbiology, 13, 876043. https://doi.org/10.3389/fmicb.2022.876043

Emerging evidence has been reported to support the involvement of the gut microbiota in the host's blood lipid and hyperlipidemia (HLP). However, there remains unexplained variation in the host's blood lipid phenotype. Herein a nonhuman primate HLP m... Read More about Transplantation of Gut Microbiota From High-Fat-Diet-Tolerant Cynomolgus Monkeys Alleviates Hyperlipidemia and Hepatic Steatosis in Rats..

The occurrence of malignancy in Trypanosoma brucei brucei by rapid passage in mice (2022)
Journal Article
Cai, X., Li, S., Zhang, P., Li, Z., Hide, G., Lai, D., & Lun, Z. (2022). The occurrence of malignancy in Trypanosoma brucei brucei by rapid passage in mice. Frontiers in Microbiology, 12, 806626. https://doi.org/10.3389/fmicb.2021.806626

Pleomorphic Trypanosoma brucei are best known for their tightly controlled cell growth and developmental program, which ensures their transmissibility and host fitness between the mammalian host and insect vector. However, after long-term adaptation... Read More about The occurrence of malignancy in Trypanosoma brucei brucei by rapid passage in mice.

Species identification and phylogenetic analysis of Leishmania isolated from patients, vectors and hares in the Xinjiang Autonomous Region, The People's Republic of China (2021)
Journal Article
Chen, Y., Liao, L., Wu, N., Gao, J., Zhang, P., Wen, Y., …Lun, Z. (2021). Species identification and phylogenetic analysis of Leishmania isolated from patients, vectors and hares in the Xinjiang Autonomous Region, The People's Republic of China. PLoS Neglected Tropical Diseases, 15(12), e0010055. https://doi.org/10.1371/journal.pntd.0010055

Visceral leishmaniasis (VL) has been declared as one of the six major tropical diseases by the World Health Organization. This disease has been successfully controlled in China, except for some areas in the western region, such as the Xinjiang Autono... Read More about Species identification and phylogenetic analysis of Leishmania isolated from patients, vectors and hares in the Xinjiang Autonomous Region, The People's Republic of China.

A new species of mammalian trypanosome, Trypanosoma (Megatrypanum) bubalisi sp. nov., found in the freshwater leech Hirudinaria manillensis (2021)
Journal Article
Su, B., Wang, J., Yang, T., Hide, G., Lai, D., & Lun, Z. (2021). A new species of mammalian trypanosome, Trypanosoma (Megatrypanum) bubalisi sp. nov., found in the freshwater leech Hirudinaria manillensis. International Journal for Parasitology, https://doi.org/10.1016/j.ijpara.2021.10.009

Leeches have long been considered potential vectors for the aquatic lineage of trypanosomes, while bloodsucking insects are generally considered as the vectors for the terrestrial lineage of trypanosomes. The freshwater leech, Hirudinaria manillensis... Read More about A new species of mammalian trypanosome, Trypanosoma (Megatrypanum) bubalisi sp. nov., found in the freshwater leech Hirudinaria manillensis.

Innate resistance to Leishmania amazonensis Infection in rat is dependent on NOS2 (2021)
Journal Article
Chen, Y., Yu, S., Wu, C., Wu, N., Shen, J., Shen, J., …Lun, Z. (2021). Innate resistance to Leishmania amazonensis Infection in rat is dependent on NOS2. Frontiers in Microbiology, 12, 733286. https://doi.org/10.3389/fmicb.2021.733286

Leishmania infection causes diverse clinical manifestations in humans. The disease outcome is complicated by the combination of many host and parasite factors. Inbred mouse strains vary in resistance to Leishmania major but are highly susceptible to... Read More about Innate resistance to Leishmania amazonensis Infection in rat is dependent on NOS2.

High resistance to Toxoplasma gondii infection in inducible nitric oxide synthase (iNOS) knockout rats (2021)
Journal Article
Wang, Z., Yu, S., Gao, J., Zhang, P., Hide, G., Yamamoto, M., …Lun, Z. (2021). High resistance to Toxoplasma gondii infection in inducible nitric oxide synthase (iNOS) knockout rats. iScience, 24(11), 103280. https://doi.org/10.1016/j.isci.2021.103280

Nitric oxide (NO) is an important immune molecule which acts against extra- and intracellular pathogens in most hosts. However, after knockout of inducible nitric oxide synthase (iNOS-/-) in Sprague Dawley (SD) rats, these iNOS-/- rats were found to... Read More about High resistance to Toxoplasma gondii infection in inducible nitric oxide synthase (iNOS) knockout rats.

Identification of an orally active carbazole aminoalcohol derivative with broad-spectrum anti-animal trypanosomiasis activity (2021)
Journal Article
Cai, X., Wang, W., Lai, D., Zhang, X., Yao, J., Yu, Y., …Lun, Z. (2021). Identification of an orally active carbazole aminoalcohol derivative with broad-spectrum anti-animal trypanosomiasis activity. Acta tropica, 219, 105919. https://doi.org/10.1016/j.actatropica.2021.105919

Animal trypanosomiasis, caused by the members of subgenus Trypanozoon (Trypanosoma brucei brucei, T. evansi and T. equiperdum), has reduced animal productivity leading to significant negative economic impacts in endemic regions. Due to limited drug d... Read More about Identification of an orally active carbazole aminoalcohol derivative with broad-spectrum anti-animal trypanosomiasis activity.