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Plasma interleukin responses as predictors of outcome stratification in patients after major trauma: a prospective observational two centre study (2023)
Journal Article

Background and objectives: There is a need to develop objective risk stratification tools to define efficient care pathways for trauma patients. Biomarker-based point of care testing may strengthen existing clinical tools currently available for this... Read More about Plasma interleukin responses as predictors of outcome stratification in patients after major trauma: a prospective observational two centre study.

Corticosteroid treatment is associated with increased filamentous fungal burden in allergic fungal disease (2017)
Journal Article
allergic fungal disease. Journal of Allergy and Clinical Immunology, 142(2), 407-414. https://doi.org/10.1016/j.jaci.2017.09.039

Background
Allergic diseases caused by fungi are common. The best understood conditions are allergic
bronchopulmonaryaspergillosis (ABPA) and severe asthma with fungal sensitisation (SAFS).
Our knowledge of the fungal microbiome (mycobiome) is li... Read More about Corticosteroid treatment is associated with increased filamentous fungal burden in allergic fungal disease.

The effects of corticosteroids on cytokine production from asthma lung lymphocytes (2014)
Journal Article
Kaur, M., Reynolds, S., Smyth, L., Simpson, K., Hall, S., & Singh, D. (2014). The effects of corticosteroids on cytokine production from asthma lung lymphocytes. International Immunopharmacology, 23(2), 581-4. https://doi.org/10.1016/j.intimp.2014.10.008

BACKGROUND

Lymphocytes play a central role in the pathophysiology of asthma. Corticosteroids have a limited effect in severe asthma and we hypothesise that lymphocytes play a central role in corticosteroid insensitivity. We investigated the effect... Read More about The effects of corticosteroids on cytokine production from asthma lung lymphocytes.

Identification of cells expressing Interleukin-17A and F in the lungs of COPD patients (2010)
Journal Article
Eustace, A., Smyth, L., Mitchell, L., Williamson, K., Plumb, J., & Singh, D. (2010). Identification of cells expressing Interleukin-17A and F in the lungs of COPD patients. Chest, https://doi.org/10.1378/chest.10-0779

Background: Lymphocytes secrete IL-17A and IL-17F which enhance innate immune responses. IL-17 expression has not been studied in COPD small airways. The aim was to quantify IL-17A and IL-17F expression in the peripheral lung tissue of COPD patients... Read More about Identification of cells expressing Interleukin-17A and F in the lungs of COPD patients.

Role of regulatory T-cells in COPD (2010)
Journal Article
Plumb, J., Smyth, L., & Singh, D. (2010). Role of regulatory T-cells in COPD

Chronic Obstructive Pulmonary Disease (COPD) is characterized by progressive and irreversible airflow limitation, caused in most cases by cigarette smoking. Increased CD8 cell numbers are associated with disease progression, and the presence of terti... Read More about Role of regulatory T-cells in COPD.

A randomized, placebo-controlled study of the effects of the p38 MAPK inhibitor SB-681323 on blood biomarkers of inflammation in COPD patients (2010)
Journal Article
Singh, D., Smyth, L., Borrill, Z., Sweeney, L., & Tal-Singer, R. (2010). A randomized, placebo-controlled study of the effects of the p38 MAPK inhibitor SB-681323 on blood biomarkers of inflammation in COPD patients. Journal of Clinical Pharmacology, 50(1), 94-100. https://doi.org/10.1177/0091270009347873

The p38 mitogen-activated protein kinase (MAPK) signaling upregulates inflammation and is known to be increased in chronic obstructive pulmonary disease (COPD). The authors assessed the pharmacology of the novel p38 MAPK inhibitor SB-681323 using blo... Read More about A randomized, placebo-controlled study of the effects of the p38 MAPK inhibitor SB-681323 on blood biomarkers of inflammation in COPD patients.

Increased airway T regulatory cells in asthmatic subjects (2010)
Journal Article
Smyth, L., Eustace, A., Kolsum, U., Blaikely, J., & Singh, D. (2010). Increased airway T regulatory cells in asthmatic subjects. Chest, 138(4), 905-912. https://doi.org/10.1378/chest.09-3079

Background: T regulatory cells (Tregs) may play a role in the suppression of effector lymphocyte activity in asthma. We hypothesized that Treg numbers would be increased in patients with more severe asthma. We also investigated the regulatory functio... Read More about Increased airway T regulatory cells in asthmatic subjects.

Inhibition of lipopolysaccharide-stimulated chronic obstructive pulmonary disease macrophage inflammatory gene expression by dexamethasone and the p38 mitogen-activated protein kinase inhibitor N-cyano-N'-(2-{[8-(2,6-difluorophenyl)-4-(4-fluoro-2-methylphenyl)-7-oxo-7,8-dihydropyrido[2,3-d] pyrimidin-2-yl]amino}ethyl)guanidine (SB706504) (2009)
Journal Article

p38 mitogen-activated protein kinase (MAPK) signaling is known to be increased in chronic obstructive pulmonary disease (COPD) macrophages. We have studied the effects of the p38 MAPK inhibitor N-cyano-N'-(2-{[8-(2,6-difluorophenyl)-4-(4-fluoro-2-met... Read More about Inhibition of lipopolysaccharide-stimulated chronic obstructive pulmonary disease macrophage inflammatory gene expression by dexamethasone and the p38 mitogen-activated protein kinase inhibitor N-cyano-N'-(2-{[8-(2,6-difluorophenyl)-4-(4-fluoro-2-methylphenyl)-7-oxo-7,8-dihydropyrido[2,3-d] pyrimidin-2-yl]amino}ethyl)guanidine (SB706504).

Increased T-regulatory cells within lymphocyte follicles in moderate COPD (2009)
Journal Article
Plumb, J., Smyth, L., Adams, H., Vestbo, J., Bentley, A., & Singh, S. (2009). Increased T-regulatory cells within lymphocyte follicles in moderate COPD. European Respiratory Journal, 34(1), 89-94. https://doi.org/10.1183/%E2%80%8B09031936.00100708

Lymphoid follicles in the lung parenchyma are a characteristic feature of chronic obstructive pulmonary disease (COPD). There are reports of altered CD4 T-regulatory cell numbers in COPD lungs, but the location of these cells within COPD lung tissue... Read More about Increased T-regulatory cells within lymphocyte follicles in moderate COPD.

CD8 chemokine receptors in chronic obstructive pulmonary disease (2008)
Journal Article
Smyth, L., Starkey, C., Gordon, F., Vestbo, J., & Singh, D. (2008). CD8 chemokine receptors in chronic obstructive pulmonary disease. https://doi.org/10.1111/j.1365-2249.2008.03729.x

Increased lung CD8 cells and their expression of chemokine receptors CXCR3 and CCR5 have been previously reported in chronic obstructive pulmonary disease (COPD). Alterations of CD8-CCR3 and -CCR4 expression and their ligands in COPD patients have no... Read More about CD8 chemokine receptors in chronic obstructive pulmonary disease.

Role of the mucosal integrin αE(CD103)β7 in tissue-restricted cytotoxicity (2007)
Journal Article
Smyth, L., Kirby, J., & Cunningham, A. (2007). Role of the mucosal integrin αE(CD103)β7 in tissue-restricted cytotoxicity. https://doi.org/10.1111/j.1365-2249.2007.03385.x

The effectiveness of lung transplantation is marred by the relatively high incidence of rejection. The lung normally contains a large population of lymphocytes in contact with the airway epithelium, a proportion of which expresses the mucosal integri... Read More about Role of the mucosal integrin αE(CD103)β7 in tissue-restricted cytotoxicity.

CD4-regulatory cells in COPD patients (2007)
Journal Article
Smyth, L., Starkey, C., Vestbo, J., & Singh, D. (2007). CD4-regulatory cells in COPD patients. Chest, 132(1), 156-163. https://doi.org/10.1378/chest.07-0083

Background: The numbers of airway CD8 and B lymphocytes are increased in COPD patients, suggesting an autoimmune process. CD4-regulatory T cells control autoimmunity but have not been studied in patients with COPD.

Objective: To compare T-regulato... Read More about CD4-regulatory cells in COPD patients.

Effect of TA-CIN (HPV 16 L2E6E7) booster immunisation in vulval intraepithelial neoplasia patients previously vaccinated with TA-HPV (vaccinia virus encoding HPV 16/18 E6E7) (2004)
Journal Article

Heterologous prime-boost vaccination schedules employing TA-HPV, a vaccinia virus encoding HPV 16/18 E6 and E7, in combination with TA-CIN, an HPV 16 L2E6E7 fusion protein, may offer advantages over the use of either agent alone for the immunotherapy... Read More about Effect of TA-CIN (HPV 16 L2E6E7) booster immunisation in vulval intraepithelial neoplasia patients previously vaccinated with TA-HPV (vaccinia virus encoding HPV 16/18 E6E7).

Immunological responses in women with human Papillomavirus Type 16 (HPV-16)-associated anogenital intraepithelial neoplasia induced by heterologous prime-boost HPV-16 oncogene vaccination (2004)
Journal Article

Purpose: The purpose is to study the immunogenicity of heterologous prime-boost human papillomavirus (HPV) oncogene vaccination in patients with anogenital intraepithelial neoplasia (AGIN).

Experimental Design: Twenty-nine women with high-grade AG... Read More about Immunological responses in women with human Papillomavirus Type 16 (HPV-16)-associated anogenital intraepithelial neoplasia induced by heterologous prime-boost HPV-16 oncogene vaccination.

Assessment of the molecular basis of the proallergenic effects of cigarette smoke (2000)
Journal Article
Smyth, L., Machado, D., Upton, A., Good, S., Aufderheide, M., & Helm, B. (2000). Assessment of the molecular basis of the proallergenic effects of cigarette smoke. Environmental Science and Technology, 34(7), 1370-1374. https://doi.org/10.1021/es9909576

Epidemiological studies indicate a link between smoking and increased risk of immunoglobulin E-mediated allergies and asthma. The molecular basis underlying cigarette smoke related respiratory disorders are ill defined, but it is known that mast cell... Read More about Assessment of the molecular basis of the proallergenic effects of cigarette smoke.

Protein and cell engineering of components of the human receptor/effector system : applications for therapy and diagnosis (1998)
Journal Article

Adaptive immune responses characterised by the synthesis of antibodies of the immunoglobulin E (IgE) isotype play an important role in type I hypersensitivity disorders and parasitic infestations, diseases which have an significant socio-economic imp... Read More about Protein and cell engineering of components of the human receptor/effector system : applications for therapy and diagnosis.