All Outputs (7)

X-ray Micro-Computed Tomography: An Emerging Technology to Analyze Vascular Calcification in Animal Models (2020)
Journal Article

Vascular calcification describes the formation of mineralized tissue within the blood vessel wall, and it is highly associated with increased cardiovascular morbidity and mortality in patients with chronic kidney disease, diabetes, and atherosclerosi... Read More about X-ray Micro-Computed Tomography: An Emerging Technology to Analyze Vascular Calcification in Animal Models.

FTI-277 inhibits smooth muscle cell calcification by up-regulating PI3K/Akt signaling and inhibiting apoptosis (2018)
Journal Article

Background
Vascular calcification is associated with increased cardiovascular morbidity and mortality in patients with atherosclerosis, diabetes and chronic kidney disease. However, no viable treatments for this condition have been identified. This... Read More about FTI-277 inhibits smooth muscle cell calcification by up-regulating PI3K/Akt signaling and inhibiting apoptosis.

Regulation of vascular smooth muscle cell calcification by syndecan-4/FGF-2/PKCα signalling and cross-talk with TGFβ (2017)
Journal Article
Borland, S. J., Morris, T. G., Borland, S. C., Morgan, M. R., Francis, S. E., Merry, C. L., & Canfield, A. E. (2017). Regulation of vascular smooth muscle cell calcification by syndecan-4/FGF-2/PKCα signalling and cross-talk with TGFβ. Cardiovascular Research, 113(13), 1639-1652. https://doi.org/10.1093/cvr/cvx178

Aims
Vascular calcification is a major cause of morbidity and mortality. Fibroblast growth factor-2 (FGF-2) plays an instructive role in osteogenesis and bone development, but its role in vascular calcification was unknown. Therefore, we investigate... Read More about Regulation of vascular smooth muscle cell calcification by syndecan-4/FGF-2/PKCα signalling and cross-talk with TGFβ.

Self-assembling peptide hydrogel for intervertebral disc tissue engineering (2016)
Journal Article
Wan, S., Borland, S., Richardson, S. M., Merry, C. L., Saiani, A., & Gough, J. E. (2016). Self-assembling peptide hydrogel for intervertebral disc tissue engineering. Acta biomaterialia, 46, 29-40. https://doi.org/10.1016/j.actbio.2016.09.033

Cell-based therapies for regeneration of intervertebral discs are regarded to hold promise for
degenerative disc disease treatment, a condition that is strongly linked to lower back pain. A de novo
self-assembling peptide hydrogel (SAPH), chosen fo... Read More about Self-assembling peptide hydrogel for intervertebral disc tissue engineering.

Temporal Development of Autonomic Dysfunction in Heart Failure: Effects of Age in an Ovine Rapid-pacing Model. (2015)
Journal Article

Heart failure (HF) is predominantly a disease of older adults and characterized by extensive sympatho-vagal imbalance leading to impaired reflex control of heart rate (HR). However, whether aging influences the development or extent of the autonomic... Read More about Temporal Development of Autonomic Dysfunction in Heart Failure: Effects of Age in an Ovine Rapid-pacing Model..

Axl tyrosine kinase protects against tubulo-interstitial apoptosis and progression of renal failure in a murine model of chronic kidney disease and hyperphosphataemia (2014)
Journal Article
Hyde, G. D., Taylor, R. F., Ashton, N., Borland, S. J., Sing Geoffrey Wu, H., Gilmore, A. P., & Canfield, A. E. (2014). Axl tyrosine kinase protects against tubulo-interstitial apoptosis and progression of renal failure in a murine model of chronic kidney disease and hyperphosphataemia. PloS one, 9(7), Article e102096. https://doi.org/10.1371/journal.pone.0102096

Chronic kidney disease (CKD) is defined as the progressive loss of renal function often involving glomerular, tubulo- interstitial and vascular pathology. CKD is associated with vascular calcification; the extent of which predicts morbidity and morta... Read More about Axl tyrosine kinase protects against tubulo-interstitial apoptosis and progression of renal failure in a murine model of chronic kidney disease and hyperphosphataemia.

The role of the anaesthetised guinea-pig in the preclinical cardiac safety evaluation of drug candidate compounds (2012)
Journal Article

Despite rigorous preclinical and clinical safety evaluation, adverse cardiac effects remain a leading cause of drug attrition and post-approval drug withdrawal. A number of cardiovascular screens exist within preclinical development. These screens do... Read More about The role of the anaesthetised guinea-pig in the preclinical cardiac safety evaluation of drug candidate compounds.