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Perivascular adipose tissue anticontractile function is mediated by both endothelial and neuronal nitric oxide synthase isoforms. (2022)
Journal Article
Saxton, S., Withers, S., & Heagerty, A. (2022). Perivascular adipose tissue anticontractile function is mediated by both endothelial and neuronal nitric oxide synthase isoforms. Journal of Vascular Research, 59(5), 1-15. https://doi.org/10.1159/000526027

The mechanism of the perivascular adipose tissue (PVAT) anticontractile effect is well characterized in rodent visceral vascular beds; however, little is known about the mechanism of PVAT anticontractile function in subcutaneous vessels. In addition,... Read More about Perivascular adipose tissue anticontractile function is mediated by both endothelial and neuronal nitric oxide synthase isoforms..

Restoring perivascular adipose tissue function in obesity using exercise (2021)
Journal Article
Saxton, S., Toms, L., Aldous, R., Withers, S., Ohanian, J., & Heagerty, A. (2021). Restoring perivascular adipose tissue function in obesity using exercise. Cardiovascular Drugs and Therapy, 35(6), 1291-1304. https://doi.org/10.1007/s10557-020-07136-0

Perivascular adipose tissue (PVAT) exerts an anti-contractile effect which is vital in regulating vascular tone. This effect is mediated via sympathetic nervous stimulation of PVAT by a mechanism which involves noradrenaline uptake through organic ca... Read More about Restoring perivascular adipose tissue function in obesity using exercise.

Interleukin-33 rescues perivascular adipose tissue anticontractile function in obesity (2020)
Journal Article
Saxton, S., Whitley, A., Potter, R., Withers, S., Grencis, R., & Heagerty, A. (2020). Interleukin-33 rescues perivascular adipose tissue anticontractile function in obesity. American journal of physiology. Heart and circulatory physiology, 319(6), H1387-H1397. https://doi.org/10.1152/ajpheart.00491.2020

Perivascular adipose tissue (PVAT) depots are metabolically active and play a major vasodilator role in healthy lean individuals. In obesity, they become inflamed and eosinophil-depleted and the anticontractile function is lost with the development o... Read More about Interleukin-33 rescues perivascular adipose tissue anticontractile function in obesity.

Perivascular adipose tissue - an immune cell metropolis (2020)
Journal Article
Saxton, S., Heagerty, A., & Withers, S. (2020). Perivascular adipose tissue - an immune cell metropolis. Experimental Physiology, 105(9), 1440-1443. https://doi.org/10.1113/EP087872

What is the topic of this review? The review discusses how eosinophils can contribute to the function of perivascular adipose tissue and explores the mechanisms involved. What advances does it highlight? Understanding the communication between the ce... Read More about Perivascular adipose tissue - an immune cell metropolis.

MiRNAs as novel adipokines : obesity-related circulating MiRNAs influence chemosensitivity in cancer patients (2020)
Journal Article
Withers, S., Dewhurst, T., Hammond, C., & Topham, C. (2020). MiRNAs as novel adipokines : obesity-related circulating MiRNAs influence chemosensitivity in cancer patients. Non-Coding RNA, 6(1), e5. https://doi.org/10.3390/ncrna6010005

Adipose tissue is an endocrine organ, capable of regulating distant physiological processes in other tissues via the release of adipokines into the bloodstream. Recently, circulating adipose-derived microRNAs (miRNAs) have been proposed as a novel cl... Read More about MiRNAs as novel adipokines : obesity-related circulating MiRNAs influence chemosensitivity in cancer patients.

P735 Interleukin-33 induced eosinophilia restores perivascular adipose tissue function in obesity (2019)
Journal Article
Saxton, S., Potter, R., Withers, S., Grencis, R., & Heagerty, A. (2019). P735 Interleukin-33 induced eosinophilia restores perivascular adipose tissue function in obesity. European Heart Journal, 40(Supple), https://doi.org/10.1093/eurheartj/ehz747.0339

Abstract Background/Purpose Perivascular adipose tissue (PVAT) is essential in the modulation of vascular tone. Recently we have shown that resident eosinophils play a vital role in regulating PVAT function. In obesity, eosinophil numbers are reduced... Read More about P735 Interleukin-33 induced eosinophilia restores perivascular adipose tissue function in obesity.

Perivascular adipose tissue contributes to the modulation of vascular tone in vivo (2019)
Journal Article
Saxton, S., Withers, S., Nyvad, J., Mazur, A., Matchkov, V., Heagerty, A., & Aalkjær, C. (2019). Perivascular adipose tissue contributes to the modulation of vascular tone in vivo. Journal of Vascular Research, 56(6), 320-332. https://doi.org/10.1159/000502689

Perivascular adipose tissue (PVAT) reduces vascular tone in isolated arteries in vitro, however there are no studies of PVAT effects on vascular tone in vivo. In vitro adipocyte β3-adrenoceptors play a role in PVAT function via secretion of the vasod... Read More about Perivascular adipose tissue contributes to the modulation of vascular tone in vivo.

Mechanistic links between obesity, diabetes, and blood pressure : role of perivascular adipose tissue (2019)
Journal Article
Saxton, S., Clark, B., Withers, S., Eringa, E., & Heagerty, A. (2019). Mechanistic links between obesity, diabetes, and blood pressure : role of perivascular adipose tissue. Physiological Reviews, 99(4), 1701-1763. https://doi.org/10.1152/physrev.00034.2018

Obesity is increasingly prevalent and is associated with substantial cardiovascular risk. Adipose tissue distribution and morphology play a key role in determining the degree of adverse effects, and a key factor in the disease process appears to be t... Read More about Mechanistic links between obesity, diabetes, and blood pressure : role of perivascular adipose tissue.

Towards a clinically relevant model for investigation of host-microbe interactions in ventilator-associated pneumonia (2019)
Journal Article
Tompsett, A., Ngoc ngo, L., Goodhead, I., Withers, S., & Latimer, J. (2019). Towards a clinically relevant model for investigation of host-microbe interactions in ventilator-associated pneumonia. Access Microbiology, 1(1A), https://doi.org/10.1099/acmi.ac2019.po0422

Ventilator-associated pneumonia (VAP) is amongst the most common healthcare-associated infections worldwide. Current understanding of the underlying mechanisms has focussed on either the microbiological or physiological elements but host-microbe inte... Read More about Towards a clinically relevant model for investigation of host-microbe interactions in ventilator-associated pneumonia.

Emerging roles of sympathetic nerves and inflammation in perivascular adipose tissue (2019)
Journal Article
Saxton, S., Withers, S., & Heagerty, A. (2019). Emerging roles of sympathetic nerves and inflammation in perivascular adipose tissue. Cardiovascular Drugs and Therapy, 33(2), 245-259. https://doi.org/10.1007/s10557-019-06862-4

Perivascular adipose tissue (PVAT) is no longer recognised as simply a structural support for the vasculature, and we now know that PVAT releases vasoactive factors which modulate vascular function. Since the discovery of this function in 1991, PVAT... Read More about Emerging roles of sympathetic nerves and inflammation in perivascular adipose tissue.

β3-adrenoceptor stimulation of perivascular adipocytes leads to increased fat cell-derived nitric oxide and vascular relaxation in small arteries (2018)
Journal Article
Bussey, C., Withers, S., Saxton, S., Bodagh, N., Aldous, R., & Heagerty, A. (2018). β3-adrenoceptor stimulation of perivascular adipocytes leads to increased fat cell-derived nitric oxide and vascular relaxation in small arteries. British Journal of Pharmacology, 175(18), 2685-3698. https://doi.org/10.1111/bph.14433

BACKGROUND AND PURPOSE In response to norepinephrine healthy perivascular adipose tissue (PVAT) exerts an anticontractile effect on adjacent small arterial tissue. Organ bath solution transfer experiments have demonstrated the release of PVAT-deriv... Read More about β3-adrenoceptor stimulation of perivascular adipocytes leads to increased fat cell-derived nitric oxide and vascular relaxation in small arteries.

Modulation of vascular reactivity by perivascular adipose tissue (PVAT) (2018)
Journal Article
Agabiti Rosei, C., Paini, A., De Ciuceis, C., Withers, S., Greenstein, A., Heagerty, A., & Rizzoni, D. (2018). Modulation of vascular reactivity by perivascular adipose tissue (PVAT). Current Hypertension Reports, 20(44), https://doi.org/10.1007/s11906-018-0835-5

Purpose of Review: In this review we discuss the role of perivascular adipose tissue (PVAT) in the modulation of vascular contractility and arterial pressure, focusing on the role of the renin-angiotensin-aldosterone system and oxidative stress/infla... Read More about Modulation of vascular reactivity by perivascular adipose tissue (PVAT).

Role of sympathetic nerves and adipocyte catecholamine uptake in the vasorelaxant function of perivascular adipose tissue. (2018)
Journal Article
Saxton, S., Ryding, K., Aldous, R., Withers, S., Ohanian, J., & Heagerty, A. (2018). Role of sympathetic nerves and adipocyte catecholamine uptake in the vasorelaxant function of perivascular adipose tissue. Arteriosclerosis, Thrombosis, and Vascular Biology, 38(4), 880-891. https://doi.org/10.1161/ATVBAHA.118.310777

Objective: Healthy perivascular adipose tissue (PVAT) exerts an anticontractile effect on resistance arteries which is vital in regulating arterial tone. Activation of β3 -adrenoceptors by sympathetic nerve-derived NA (noradrenaline) may be implicate... Read More about Role of sympathetic nerves and adipocyte catecholamine uptake in the vasorelaxant function of perivascular adipose tissue..

Eosinophils are key regulators of perivascular adipose tissue and vascular functionality (2017)
Journal Article
vascular functionality. Scientific reports, 7, 44571. https://doi.org/10.1038/srep44571

Obesity impairs the relaxant capacity of adipose tissue surrounding the vasculature (PVAT) and has been implicated in resultant obesity-related hypertension and impaired glucose intolerance. Resident immune cells are thought to regulate adipocyte a... Read More about Eosinophils are key regulators of perivascular adipose tissue and vascular functionality.

Obesity-related perivascular adipose tissue damage is reversed by sustained weight loss in the rat (2016)
Journal Article
Bussey, C., Withers, S., Aldous, R., Edwards, G., & Heagerty, A. (2016). Obesity-related perivascular adipose tissue damage is reversed by sustained weight loss in the rat. Arteriosclerosis, Thrombosis, and Vascular Biology, 36(7), 1377-1385. https://doi.org/10.1161/ATVBAHA.116.307210

Objective – Perivascular adipose tissue (PVAT) exerts an anticontractile effect in response to various vasoconstrictor agonists and this is lost in obesity. A recent study reported that bariatric surgery reverses the damaging effects of obesity on PV... Read More about Obesity-related perivascular adipose tissue damage is reversed by sustained weight loss in the rat.

Mechanisms of adiponectin-associated perivascular function in vascular disease (2014)
Journal Article
Withers, S., Bussey, C., Saxton, S., Melrose, H., Watkins, A., & Heagerty, A. (2014). Mechanisms of adiponectin-associated perivascular function in vascular disease. Arteriosclerosis, Thrombosis, and Vascular Biology, 34(8), 1637-42. https://doi.org/10.1161/ATVBAHA.114.303031

The concept that fat cells could influence the circulation and indeed cardiac function has been in existence for ≥20 years and has gained a wide interest and no less excitement as evidence has accrued to suggest that such effects may be profound enou... Read More about Mechanisms of adiponectin-associated perivascular function in vascular disease.