All Outputs (2)

Novel therapies for cancer treatment : designing high affinity and selectivity ligands against SIRT1 (2015)
Presentation / Conference
Al-Sudani, B., Krstic- Demonacos, M., & Ragazzon, P. (2015, June). Novel therapies for cancer treatment : designing high affinity and selectivity ligands against SIRT1. Poster presented at EuroMedLab Paris 2015, Paris, France

The word ‘sirtuin’ (SIR) stands for Silent Information Regulator. SIRT1 is the most studied mammalian sirtuin and predominantly localises to the nucleus. Many sirtuins targets are involved in cancer and in many types of cancers, SIRT1 is found to be... Read More about Novel therapies for cancer treatment : designing high affinity and selectivity ligands against SIRT1.

Applications of p53 interactome analysis to personalised drug discovery (2014)
Presentation / Conference
Hussain, M., Stutchbury, B., Tian, K., Atalay, R., Schwartz, J., & Krstic-Demonacos, M. (2014, April). Applications of p53 interactome analysis to personalised drug discovery. Presented at Conference: International Work-Conference on Bioinformatics and Biomedical Engineering (IWBBIO 2014), Universidad de Granada, Granada, Spain

The stress responsive transcription factor p53 is a powerful tumor suppressor implicated in over 50 % of all human cancers. The complexity and nonlinear dynamics of p53 network coupled with extensive literature is challenging. Sys-tems biology method... Read More about Applications of p53 interactome analysis to personalised drug discovery.