All Outputs (5)

Targeting c-met in sonic hedgehog medulloblastomas (2022)
Thesis
Morlando, S. Targeting c-met in sonic hedgehog medulloblastomas. (Thesis). University of Salford

Medulloblastoma (MB), a cerebellar tumour primarily diagnosed in children, is the most common malignant brain tumour consisting of four molecular subgroups: Wingless (WNT), Sonic Hedgehog (SHH), Group 3 and Group 4. Although the 70-75% of MB patients... Read More about Targeting c-met in sonic hedgehog medulloblastomas.

Novel copper-catalysed coupling reactions of diphenylmethane (2021)
Thesis
Breski, A. (in press). Novel copper-catalysed coupling reactions of diphenylmethane. (Dissertation). University of Salford

In this thesis, a novel synthesis of the drug fendiline was attempted. Fendiline was sold commercially as an angina therapeutic, and recent studies have shown that it is also anti-malarial and has activity against cancers with a high mortality rate.... Read More about Novel copper-catalysed coupling reactions of diphenylmethane.

Establishing a structure-activity-relationship for small molecule non-sugar glycomimetics (2021)
Thesis
Dobiecki-Davies, J. Establishing a structure-activity-relationship for small molecule non-sugar glycomimetics. (Dissertation). University of Salford

DAOY Medullablastoma cells are highly invasive, mobile and can cause severe neurological and physical illness in patients affected by this cancer. Previous work by Wilkinson & Co-workers (2017) showed that some small-molecule non-sugar glycomimetic d... Read More about Establishing a structure-activity-relationship for small molecule non-sugar glycomimetics.

Synthesis of small-molecule HGF-Met inhibitors for use in preventing cell motility (2020)
Thesis
Bunte, A. Synthesis of small-molecule HGF-Met inhibitors for use in preventing cell motility. (Dissertation). University of Salford

Glycosaminoglycans are becoming more and more focused upon as a research topic due to the broad use they have in aiding wound healing and preventing cell motility through competitive inhibition of the HGF-Met pathway. This pathway is extremely import... Read More about Synthesis of small-molecule HGF-Met inhibitors for use in preventing cell motility.

Investigating the anti-proliferative properties and their mechanism(s) of action of marine derived glycosaminoglycans from two marine sources (2020)
Thesis
two marine sources. (Dissertation). University of Salford

The purpose of this study was to investigate the chemotherapeutic properties of marine derived glycosaminoglycans (GAGs) and investigate their mechanism(s) of action. The secondary purpose was to investigate differences between the already studied co... Read More about Investigating the anti-proliferative properties and their mechanism(s) of action of marine derived glycosaminoglycans from two marine sources.