All Outputs (2)

Synthesis and evaluation of novel kinase inhibitors as anti-cancer agents (2012)
Thesis
Kemp, T. Synthesis and evaluation of novel kinase inhibitors as anti-cancer agents. (Thesis). University of Salford

Disruption of protein kinase signalling pathways is often associated with cancer. The RhoA/ROCK kinase pathway has been shown to be constitutively expressed in many cancers and has also been shown to be involved in metastasis and apoptosis. ROCK is... Read More about Synthesis and evaluation of novel kinase inhibitors as anti-cancer agents.

Studies on the effect of asparaginase in paediatric leukaemia (2010)
Thesis
Coe, N. Studies on the effect of asparaginase in paediatric leukaemia. (Thesis). Salford : University of Salford

Asparaginase, an important agent in the treatment of acute lymphoblastic leukaemia, is thought to cause cell death by depriving lymphoblasts of asparagine. However, because asparaginase also hydrolyses glutamine, a critical fuel for normal lymphoc... Read More about Studies on the effect of asparaginase in paediatric leukaemia.