All Outputs (4)

Synthesis and evaluation of novel kinase inhibitors as anti-cancer agents (2012)
Thesis
Kemp, T. Synthesis and evaluation of novel kinase inhibitors as anti-cancer agents. (Thesis). University of Salford

Disruption of protein kinase signalling pathways is often associated with cancer. The RhoA/ROCK kinase pathway has been shown to be constitutively expressed in many cancers and has also been shown to be involved in metastasis and apoptosis. ROCK is... Read More about Synthesis and evaluation of novel kinase inhibitors as anti-cancer agents.

Image [&] Narrative journal editorship (in 2 issues) - The story of things: reading narrative in the visual (2011)
Other
Carson, J., & Miller, R. (2011). Image [&] Narrative journal editorship (in 2 issues) - The story of things: reading narrative in the visual. Belgium

Based on the conference convened by Carson & Miller to accompany their project The Story of Things, these two journal issues of Image [&] Narrative explore the relationship between narrative and the visual. Issue 1: ‘Introduction’, Carson &... Read More about Image [&] Narrative journal editorship (in 2 issues) - The story of things: reading narrative in the visual.

Mechanistic studies on aziridinylbenzoquinones and CCNU [l-(2-chloroethyl)- 3-cyclohexyl-l-nitrosourea] in cultured tumour cells (2007)
Thesis
Ben Raba, F. Mechanistic studies on aziridinylbenzoquinones and CCNU [l-(2-chloroethyl)- 3-cyclohexyl-l-nitrosourea] in cultured tumour cells. (Thesis). University of Salford

This work is concerned with the action of two different anticancer drugs which can alkylate DNA in tumour cells. The first alkylating agent studied was CCNU [(l-(2-chloroethyl)-3-cyclohexyl-lnitrosourea, Lomustine]. This is a well established clin... Read More about Mechanistic studies on aziridinylbenzoquinones and CCNU [l-(2-chloroethyl)- 3-cyclohexyl-l-nitrosourea] in cultured tumour cells.

Anti-tumour properties of novel diaziridinylquinones (2001)
Thesis
Di Francesco, A. Anti-tumour properties of novel diaziridinylquinones. (Thesis). Salford : University of Salford

This work is concerned with the synthesis and potential anti-tumour properties of novel Diaziridinylquinones. These types of compounds are usually activated by bioreduction to form cytotoxic species, which alkylate DNA and block cells in the G 2 /M... Read More about Anti-tumour properties of novel diaziridinylquinones.