Microwave assisted synthesis of novel bis-flavone dimers as new anticancer agents (2018)
Journal Article
Ragazzon, P., McGown, A., Ragazzon-Smith, A., Hadfield, J., & Potgetier, H. (2018). Microwave assisted synthesis of novel bis-flavone dimers as new anticancer agents. Letters in Organic Chemistry, 16(1), 66-75. https://doi.org/10.2174/1570178615666180621094529

In this study we describe a microwave based click chemistry method used to prepare a family of novel bis-flavone dimers. The substituted 7-hydroxy and 4’-hydroxy flavonoids were linked through a triazole ring. The compounds were easily synthesized an... Read More about Microwave assisted synthesis of novel bis-flavone dimers as new anticancer agents.

Dibenzoyl-methane derivatives as potential and exciting new therapy for the treatment of childhood bone cancer (2016)
Journal Article
Almelah, E., Smith, D., McGown, A., Aziz, A., Potgieter, H., & Ragazzon, P. (2016). Dibenzoyl-methane derivatives as potential and exciting new therapy for the treatment of childhood bone cancer. Anticancer Research, 36(11), 6043-6050. https://doi.org/10.21873/anticanres.11193

Abstract. Childhood bone cancer though rare, has very limited treatment choices, with poor survival rates and often involving amputation. We have developed a novel molecule, 2', 4'-dihydroxy-dithion-dibenzoyl-methane and tested it on hepatic, colon,... Read More about Dibenzoyl-methane derivatives as potential and exciting new therapy for the treatment of childhood bone cancer.