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Tubulin-binding Dibenz[c,e]oxepines as Colchinol analogues for targeting tumour vasculature (2010)
Journal Article
targeting tumour vasculature. Organic and Biomolecular Chemistry, 9(1), 219-231. https://doi.org/10.1039/c0ob00500b

Various methoxy- and hydroxy-substituted dibenz[c,e]oxepines were prepared via the copper(I)-induced coupling of ether-tethered arylstannanes or the dehydrative cyclisation of 1,1'- biphenyl-2,2'-dimethanols, assembled using the Ullmann cross-coupl... Read More about Tubulin-binding Dibenz[c,e]oxepines as Colchinol analogues for targeting tumour vasculature.

Inflicting controlled nonthermal damage to subcellular structures by laser-activated gold nanoparticles (2010)
Journal Article
Krpetic, Z., Nativo, P., Sée, V., Prior, I., Brust, M., & Volk, M. (2010). Inflicting controlled nonthermal damage to subcellular structures by laser-activated gold nanoparticles. Nano Letters, 10(11), 4549-4554. https://doi.org/10.1021/nl103142t

We show that low-intensity laser irradiation of cancer cells containing endosomal gold nanoparticles leads to endosome rupture and escape of the nanoparticles into the cytosol without affecting the cells’ viability. The low light intensity of our exp... Read More about Inflicting controlled nonthermal damage to subcellular structures by laser-activated gold nanoparticles.

Phagocytosis of biocompatible gold nanoparticles (2010)
Journal Article
Krpeticc, Z., Porta, F., Caneva, E., Dal Santo, V., & Scarì, G. (2010). Phagocytosis of biocompatible gold nanoparticles. Langmuir, 26(18), 14799-14805. https://doi.org/10.1021/la102758f

We report the evidence for the cellular uptake of gold nanoparticles via the phagocytosis mechanism in murine macrophage cells strongly supported by TEM and optical microscopy. Nanoparticles were prepared using several biocompatible molecules of choi... Read More about Phagocytosis of biocompatible gold nanoparticles.

Isolation of 1,4-Li2-C6H4 and its reaction with [(Ph3P)AuCl] (2010)
Journal Article
Flower, K., Mcgown, A., Miles, P., Pritchard, R., & Warren, J. (2010). Isolation of 1,4-Li2-C6H4 and its reaction with [(Ph3P)AuCl]. Dalton Transactions, 39(14), 3509-3520. https://doi.org/10.1039/b925355f

The difficulty in generating 1,4-Li2-C6H4 utilising the lithium halogen exchange reaction on 1,4-Br2-C6H4, 1,4-I2-C6H4 and 1-Br-4-I-C6H4 is revisited and only on treatment of 1,4-I2-C6H4 with 2 molar equivalents of n-BuLi can 1,4-Li2-C6H4 1 be isolat... Read More about Isolation of 1,4-Li2-C6H4 and its reaction with [(Ph3P)AuCl].

Cross-resistance of Cry1Ab-selected Asian corn borer to other Cry toxins (2010)
Journal Article
Xu, L., Wang, Z., Zhang, J., Ferry, N., & Gatehouse, A. (2010). Cross-resistance of Cry1Ab-selected Asian corn borer to other Cry toxins. Journal of Applied Entomology, 134(5), 429-438. https://doi.org/10.1111/j.1439-0418.2010.01517.x

The Asian corn borer, Ostrinia furnacalis (Guene´e) (Lepidoptera: Crambidae), is the most important insect pest of maize in China. Despite the proven track record of biotech Bacillus thuringiensis (Bt) maize to provide an effective means to control l... Read More about Cross-resistance of Cry1Ab-selected Asian corn borer to other Cry toxins.

Can the solid state structures of the dihalogen adducts R3EX2 (E = P, As; R = alkyl, aryl; X = Br, I) with the molecular spoke geometry be considered good mimics of the gold(I) systems [(R3E)AuX] (E = As, P; R = alkyl, aryl; X = Cl, Br, I)? (2010)
Journal Article
Barnes, N., Flower, K., Fyyaz, S., Godfrey, S., Mcgown, A., Miles, P., …Warren, J. (2010). Can the solid state structures of the dihalogen adducts R3EX2 (E = P, As; R = alkyl, aryl; X = Br, I) with the molecular spoke geometry be considered good mimics of the gold(I) systems [(R3E)AuX] (E = As, P; R = alkyl, aryl; X = Cl, Br, I)?. CrystEngComm, 12(3), 784-794. https://doi.org/10.1039/b917245a

The solid-state structures of compounds of the type R3EX2 and [(R3E)AuX] (R = alkyl, aryl, E = As, P, X = Cl, Br, I) have been compared on the basis that they have similar molecular shape and volume with a view to determine whether this is a good app... Read More about Can the solid state structures of the dihalogen adducts R3EX2 (E = P, As; R = alkyl, aryl; X = Br, I) with the molecular spoke geometry be considered good mimics of the gold(I) systems [(R3E)AuX] (E = As, P; R = alkyl, aryl; X = Cl, Br, I)?.

T regulatory cells in cancer: recent advances and therapeutic potential (2010)
Journal Article
Elkord, E., Alcantar-Orozco, E., Dovedi, S., & Tran, D. (2010). T regulatory cells in cancer: recent advances and therapeutic potential. Expert Opinion on Biological Therapy, 10(11), 1573-1586. https://doi.org/10.1517/14712598.2010.529126

IMPORTANCE OF THE FIELD: The active suppression of immune responses against tumor is a major barrier to the likely success of cancer immunotherapy. There is now compelling evidence implicating T regulatory cells (Tregs) as being key players driving i... Read More about T regulatory cells in cancer: recent advances and therapeutic potential.

Investigation of the effects of schistosoma mansoni eggs on hepatic stellate cell phenotype (2010)
Thesis
Anthony, B. Investigation of the effects of schistosoma mansoni eggs on hepatic stellate cell phenotype. (Thesis). Salford : University of Salford

Schistosomiasis is one of the most important helminth infections in man, infecting an estimated 200 million people worldwide leaving 20 million people with severe morbidity and causing 20,000 deaths a year. Of chronically infected patients approxi... Read More about Investigation of the effects of schistosoma mansoni eggs on hepatic stellate cell phenotype.

The effect of Msh2 knockdown on methylating agent induced toxicity in DNA glycosylase deficient cells (2010)
Journal Article
Cooley, N., Elder, R., & Povey, A. (2010). The effect of Msh2 knockdown on methylating agent induced toxicity in DNA glycosylase deficient cells. Toxicology, 268(1-2), 111-117. https://doi.org/10.1016/j.tox.2009.12.008

The DNA structure recognition protein MSH2 is an important protein in DNA mismatch repair due to its role in initiating the repair process. To examine the potential interactions between mismatch repair and base excision repair (BER) we have examined... Read More about The effect of Msh2 knockdown on methylating agent induced toxicity in DNA glycosylase deficient cells.

Phase phenomena in supported lipid films under varying electric potential (2010)
Journal Article
Brukhno, A., Akinshina, A., Coldrick, Z., Nelson, A., & Auer, S. (2011). Phase phenomena in supported lipid films under varying electric potential. Soft Matter, 7(3), 1006-1017. https://doi.org/10.1039/C0SM00724B

We model cyclic voltammetry experiments on supported lipid films where a non-trivial dependence of the capacitance on the applied voltage is observed. Previously, based on a mean-field treatment of the Flory–Huggins type, under the assumption of stro... Read More about Phase phenomena in supported lipid films under varying electric potential.