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Immune checkpoints in circulating and tumor-Infiltrating CD4 + T Cell Subsets in Colorectal cancer patients (2019)
Journal Article
Toor, S., Murshed, K., Al-Dhaheri, M., Khawar, M., Abu Nada, M., & Elkord, E. (2019). Immune checkpoints in circulating and tumor-Infiltrating CD4 + T Cell Subsets in Colorectal cancer patients. Frontiers in Immunology, 10, 2936. https://doi.org/10.3389/fimmu.2019.02936

Blockade of inhibitory immune checkpoints (ICs) is a promising therapeutic approach; however, it has shown limited success in some cancers including colorectal cancer (CRC). The tumor microenvironment (TME) is largely responsible for response to ther... Read More about Immune checkpoints in circulating and tumor-Infiltrating CD4 + T Cell Subsets in Colorectal cancer patients.

Influence of synthesis conditions on the structure of nickel nanoparticles and their reactivity in selective asymmetric hydrogenation (2019)
Journal Article
Arrigo, R., Gallarati, S., Schuster, M., Seymour, J., Gianolio, D., da Silva, I., …Held, G. (2020). Influence of synthesis conditions on the structure of nickel nanoparticles and their reactivity in selective asymmetric hydrogenation. ChemCatChem, 12(5), 1491-1503. https://doi.org/10.1002/cctc.201901955

Unsupported and SiO2-supported Ni nanoparticles (NPs), were synthesised via hot-injection colloidal route using oleylamine (OAm) and trioctylphosphine (TOP) as reducing and protective agents, respectively. By adopting a multi-length scale structural... Read More about Influence of synthesis conditions on the structure of nickel nanoparticles and their reactivity in selective asymmetric hydrogenation.

FoxO3a as a positive prognostic marker and a therapeutic target in Tamoxifen-resistant breast cancer (2019)
Journal Article
Pellegrino, M., Rizza, P., Donà, A., Nigro, A., Ricci, E., Fiorillo, M., …Morelli, C. (2019). FoxO3a as a positive prognostic marker and a therapeutic target in Tamoxifen-resistant breast cancer. Cancers, 11(12), e1858. https://doi.org/10.3390/cancers11121858

Background: Resistance to endocrine treatments is a major clinical challenge in the management of estrogen receptor positive breast cancers. Although multiple mechanisms leading to endocrine resistance have been proposed, the poor outcome of this sub... Read More about FoxO3a as a positive prognostic marker and a therapeutic target in Tamoxifen-resistant breast cancer.

Thioalbamide, a thioamidated peptide from amycolatopsis alba, affects tumor growth and stemness by inducing metabolic dysfunction and oxidative stress (2019)
Journal Article
Frattaruolo, L., Fiorillo, M., Brindisi, M., Curcio, R., Dolce, V., Lacret, R., …Cappello, A. (2019). Thioalbamide, a thioamidated peptide from amycolatopsis alba, affects tumor growth and stemness by inducing metabolic dysfunction and oxidative stress. Cells, 8(11), e1408. https://doi.org/10.3390/cells8111408

Thioalbamide, a thioamidated peptide biosynthesized by Amycolatopsis alba, is a thioviridamide-like molecule, and is part of a family of natural products representing a focus of biotechnological and pharmaceutical research in recent years due to thei... Read More about Thioalbamide, a thioamidated peptide from amycolatopsis alba, affects tumor growth and stemness by inducing metabolic dysfunction and oxidative stress.

Is digital health care more equitable? The framing of health inequalities within England's digital health policy 2010–2017 (2019)
Journal Article
Rich, E., Miah, A., & Lewis, S. (2019). Is digital health care more equitable? The framing of health inequalities within England's digital health policy 2010–2017. Sociology of Health and Illness, 41(S1), 31-49. https://doi.org/10.1111/1467-9566.12980

Informed by a discourse analysis, this article examines the framing of equity within the UK's digital health policies between 2010 and 2017, focusing on England's development of NHS Digital and its situation within the UK Government's wider digital s... Read More about Is digital health care more equitable? The framing of health inequalities within England's digital health policy 2010–2017.

MAT Seroprevalence infers low rates of Toxoplasma gondii in domestic pigs from Yucatan, Mexico (2019)
Journal Article
Cubas-Atienzar, A., Hide, G., & Smith, J. (2019). MAT Seroprevalence infers low rates of Toxoplasma gondii in domestic pigs from Yucatan, Mexico. Journal of Parasitology, 105(5), 738-747. https://doi.org/10.1645/18-188

Toxoplasma gondii is a zoonotic parasite of worldwide distribution. The consumption of infected pork meat has been suggested to be an important source for human infection in the tropical area of Yucatan, Mexico. We performed a cross-sectional study o... Read More about MAT Seroprevalence infers low rates of Toxoplasma gondii in domestic pigs from Yucatan, Mexico.

Sirtuin family members selectively regulate autophagy in osteosarcoma and mesothelioma cells in response to cellular stress (2019)
Journal Article
Garva, R., Thepmalee, C., Yasamut, U., Sudsaward, S., Guazzelli, A., Rajendran, R., …Demonacos, C. (2019). Sirtuin family members selectively regulate autophagy in osteosarcoma and mesothelioma cells in response to cellular stress. Frontiers in Oncology, 9, 949. https://doi.org/10.3389/fonc.2019.00949

The class III NAD+ dependent deacetylases-sirtuins (SIRTs) link transcriptional regulation to DNA damage response and reactive oxygen species generation thereby modulating a wide range of cellular signalling pathways. Here the contribution of SIRT1,... Read More about Sirtuin family members selectively regulate autophagy in osteosarcoma and mesothelioma cells in response to cellular stress.

Tunicamycin induced endoplasmatic reticulum changes in endothelial cells investigated in vitro by confocal Raman imaging (2019)
Journal Article
endothelial cells investigated in vitro by confocal Raman imaging. Analyst, 144(22), 6561-6569. https://doi.org/10.1039/C9AN01456J

This paper describes how tunicamycin (Tu), the most widely used pharmacological agent for inducing endoplasmic reticulum (ER) stress, interacts with endothelial cells. Our results show that tunicamycin enters the cells and accumulates within the ER a... Read More about Tunicamycin induced endoplasmatic reticulum changes in endothelial cells investigated in vitro by confocal Raman imaging.

Interaction of microtubules and actin during the post-fusion phase of exocytosis (2019)
Journal Article
Muller, M., Schempp, R., Lutz, A., Felder, T., Felder, E., & Miklavc, P. (2019). Interaction of microtubules and actin during the post-fusion phase of exocytosis. Scientific reports, 9, 11973. https://doi.org/10.1038/s41598-019-47741-0

Exocytosis is the intracellular trafficking step where a secretory vesicle fuses with the plasma membrane to release vesicle content. Actin and microtubules both play a role in exocytosis; however, their interplay is not understood. Here we study the... Read More about Interaction of microtubules and actin during the post-fusion phase of exocytosis.

SPARC 2019 Fake news & home truths : Salford postgraduate annual research conference book of abstracts (2019)
Book
Aarons, T., Abduljawad, S. A. S., Aboelkheir, A., Addis, M. C., Adeboye, O., Adeniyi, I. A., …Yusup, N. H. (2019). E. M. Barnes, D. Greensmith, M. Griffiths, U. Hurley, T. Ireland, C. Starbuck, …D. Whitnall (Eds.), SPARC 2019 Fake news & home truths : Salford postgraduate annual research conference book of abstracts. Salford, UK: University of Salford

Welcome to the Book of Abstracts for the 2019 SPARC conference. This year we not only celebrate the work of our PGRs but also our first ever Doctoral School Best Supervisor awards, which makes this year’s conference extra special. Once again we have... Read More about SPARC 2019 Fake news & home truths : Salford postgraduate annual research conference book of abstracts.

What can independent research for Mesothelioma achieve to treat this orphan disease? (2019)
Journal Article
Guazzelli, A., Meysami, P., Bakker, E., Bonanni, E., Demonacos, C., Krstic- Demonacos, M., & Mutti, L. (2019). What can independent research for Mesothelioma achieve to treat this orphan disease?. Expert Opinion on Investigational Drugs, 28(8), 719-732. https://doi.org/10.1080/13543784.2019.1638363

Introduction: Malignant pleural mesothelioma (MPM) is a rare neoplasm with a poor prognosis, as current therapies are ineffective. Despite the increased understanding of the molecular biology of mesothelioma, there is still a lack of drugs that drama... Read More about What can independent research for Mesothelioma achieve to treat this orphan disease?.

High frequency of infection of lung cancer patients with the parasite Toxoplasma gondii (2019)
Journal Article
Bajnok, J., Tarabulsi, M., Carlin, H., Bown, K., Southworth, T., Dungwa, J., …Hide, G. (2019). High frequency of infection of lung cancer patients with the parasite Toxoplasma gondii. ERJ Open Research, 5(2), 1-10. https://doi.org/10.1183/23120541.00143-2018

Toxoplasma gondii is an intracellular protozoan parasite that can cause a wide range of clinical conditions, including miscarriage and pneumonia. The global prevalence is 30% in humans but varies locally (e.g. UK is typically 10%). The association be... Read More about High frequency of infection of lung cancer patients with the parasite Toxoplasma gondii.

The biochemical role of the human NEIL1 and NEIL3 DNA glycosylases on model DNA replication forks (2019)
Journal Article
Albelazi, M., Martin, P., Mohammed, S., Mutti, L., Parsons, J., & Elder, R. (2019). The biochemical role of the human NEIL1 and NEIL3 DNA glycosylases on model DNA replication forks. Genes, 10(4), 315. https://doi.org/10.3390/genes10040315

Endonuclease VIII-like (NEIL) 1 and 3 proteins eliminate oxidative DNA base damage and psoralen DNA interstrand crosslinks through initiation of base excision repair. Current evidence points to a DNA replication associated repair function of NEIL1 an... Read More about The biochemical role of the human NEIL1 and NEIL3 DNA glycosylases on model DNA replication forks.

Doxycycline, Azithromycin and vitamin C (DAV) : a potent combination therapy for targeting mitochondria and eradicating cancer stem cells (CSCs) (2019)
Journal Article
Fiorillo, M., Tóth, F., Sotgia, F., & Lisanti, M. (2019). Doxycycline, Azithromycin and vitamin C (DAV) : a potent combination therapy for targeting mitochondria and eradicating cancer stem cells (CSCs). Aging, 11(8), 2202-2216. https://doi.org/10.18632/aging.101905

Here, we devised a new strategy for eradicating cancer stem cells (CSCs), via a "synthetic-metabolic" approach, involving two FDA-approved antibiotics and a dietary vitamin supplement. This approach was designed to induce a "rho-zero-like" phenotype... Read More about Doxycycline, Azithromycin and vitamin C (DAV) : a potent combination therapy for targeting mitochondria and eradicating cancer stem cells (CSCs).

Enhancing evolution : the transhuman case for gene doping (2019)
Book Chapter
Miah, A. (2019). Enhancing evolution : the transhuman case for gene doping. In J. Lightfoot, M. Hubal, & S. Roth (Eds.), The Routledge Handbook of Sport and Exercise Systems Genetics (463-474). Abingdon, UK: Routledge

On the high structural heterogeneity of Fe impregnated graphite-carbon catalysts from Fe nitrate precursor (2019)
Journal Article
Arrigo, R., & Schuster, M. (2019). On the high structural heterogeneity of Fe impregnated graphite-carbon catalysts from Fe nitrate precursor. Catalysts, 9(4), 303. https://doi.org/10.3390/catal9040303

Wet impregnation is broadly applied for the synthesis of carbon supported metal/metal oxide nanostructures because of its high flexibility, simplicity and low cost. By contrast, impregnated catalysts are typified by a usually undesired nanostructural... Read More about On the high structural heterogeneity of Fe impregnated graphite-carbon catalysts from Fe nitrate precursor.

The association between Toxoplasma gondii infection and postpartum blues (2019)
Journal Article
Gao, J., He, Z., Xie, Y., Hide, G., Lai, D., & Lun, Z. (2019). The association between Toxoplasma gondii infection and postpartum blues. Journal of Affective Disorders, 250, 404-409. https://doi.org/10.1016/j.jad.2019.03.013

Introduction and Aim: Toxoplasma gondii is an intracellular protozoan parasite infecting approximately 30% of the global human population. It has often been suggested that chronic infection with T. gondii is related to personality changes and vario... Read More about The association between Toxoplasma gondii infection and postpartum blues.

Hallmarks of the cancer cell of origin : comparisons with "energetic" cancer stem cells (e-CSCs) (2019)
Journal Article
Sotgia, F., Fiorillo, M., & Lisanti, M. (2019). Hallmarks of the cancer cell of origin : comparisons with "energetic" cancer stem cells (e-CSCs). Aging, 11(3), 1065-1068. https://doi.org/10.18632/aging.101822

Here, we discuss the expected hallmark(s) of the cancer cell of origin and how this may be related to a new tumor cell phenotype, namely "energetic" cancer stem cells (e-CSCs). e-CSCs show many features that would be characteristic of the cancer cell... Read More about Hallmarks of the cancer cell of origin : comparisons with "energetic" cancer stem cells (e-CSCs).

“Energetic” cancer stem cells (e-CSCs) : a new hyper-metabolic and proliferative tumor cell phenotype, driven by mitochondrial energy (2019)
Journal Article
Fiorillo, M., Sotgia, F., & Lisanti, M. (2019). “Energetic” cancer stem cells (e-CSCs) : a new hyper-metabolic and proliferative tumor cell phenotype, driven by mitochondrial energy. Frontiers in Oncology, 8(677), https://doi.org/10.3389/fonc.2018.00677

Here, we provide the necessary evidence that mitochondrial metabolism drives the anchorage-independent proliferation of CSCs. Two human breast cancer cell lines, MCF7 [ER(+)] and MDA-MB-468 (triple-negative), were used as model systems. To directly... Read More about “Energetic” cancer stem cells (e-CSCs) : a new hyper-metabolic and proliferative tumor cell phenotype, driven by mitochondrial energy.

Cell cycle and cleavage events during in vitro cultivation of bloodstream forms of Trypanosoma lewisi, a zoonotic pathogen (2019)
Journal Article
Zhang, X., Li, S., Li, Z., He, C., Hide, G., Lai, D., & Lun, Z. (2019). Cell cycle and cleavage events during in vitro cultivation of bloodstream forms of Trypanosoma lewisi, a zoonotic pathogen. Cell Cycle, 18(5), 552-567. https://doi.org/10.1080/15384101.2019.1577651

Trypanosoma (Herpetosoma) lewisi is a globally distributed rat trypanosome, currently considered as a zoonotic pathogen; however, a detailed understanding of the morphological events occurring during the cell cycle is lacking. This study aimed to inv... Read More about Cell cycle and cleavage events during in vitro cultivation of bloodstream forms of Trypanosoma lewisi, a zoonotic pathogen.