Identification and characterisation of lignin degrading bacteria and enzymes from larval guts of the African Palm Weevil (Rhynchophorus phoenicis) (2022)
Thesis
larval guts of the African Palm Weevil (Rhynchophorus phoenicis). (Thesis). University of Salford

As developing economies continue to grow, the world’s demand for energy which currently stands at 84MB (million barrels oil) per day is projected to rise to 116 MB per day by the year 2030. The need to meet this continuous rise in demand for energy w... Read More about Identification and characterisation of lignin degrading bacteria and enzymes from larval guts of the African Palm Weevil (Rhynchophorus phoenicis).

Characterisation of a Novel Acetyl Xylan Esterase (BaAXE) screened from the Gut Microbiota of the Common Black Slug (Arion ater) (2022)
Journal Article
Madubuike, H., & Ferry, N. (2022). Characterisation of a Novel Acetyl Xylan Esterase (BaAXE) screened from the Gut Microbiota of the Common Black Slug (Arion ater). Molecules, 27(9), 2999. https://doi.org/10.3390/molecules27092999

Acetyl xylan esterases (AXEs) are enzymes capable of hydrolysing the acetyl bonds in acetylated xylan, allowing for enhanced activity of backbone-depolymerizing enzymes. Bioprospecting novel AXE is essential in designing enzyme cocktails with desired... Read More about Characterisation of a Novel Acetyl Xylan Esterase (BaAXE) screened from the Gut Microbiota of the Common Black Slug (Arion ater).

Characterization of sialic acid affinity of the binding domain of mistletoe lectin isoform one (2021)
Journal Article
Mohammed, S., & Ferry, N. (2021). Characterization of sialic acid affinity of the binding domain of mistletoe lectin isoform one. International Journal of Molecular Sciences, 22(15), e8284. https://doi.org/10.3390/ijms22158284

Sialic acid (Sia) is considered as one of the most important biomolecules of life since its derivatives and terminal orientations on cell membranes and macromolecules play a major role in many biological and pathological processes. To date, there is... Read More about Characterization of sialic acid affinity of the binding domain of mistletoe lectin isoform one.

Circular and linear : a tale of aptamer selection for the activation of SIRT1 to induce death in cancer cells (2020)
Journal Article
Al-Sudani, B., Ragazzon-Smith, A., Aziz, A., Alansari, R., Ferry, N., Krstic- Demonacos, M., & Ragazzon, P. (2020). Circular and linear : a tale of aptamer selection for the activation of SIRT1 to induce death in cancer cells. RSC Advances, 10(73), 45008-45018. https://doi.org/10.1039/D0RA07857C

It is a challenge to select the right target to treat conditions without affecting non-diseased cells. Cancer belongs to the top 10 causes of death in the world and it remains difficult to treat. Amongst cancer emerging targets, silent information re... Read More about Circular and linear : a tale of aptamer selection for the activation of SIRT1 to induce death in cancer cells.

Cross-resistance of Cry1Ab-selected Asian corn borer to other Cry toxins (2010)
Journal Article
Xu, L., Wang, Z., Zhang, J., Ferry, N., & Gatehouse, A. (2010). Cross-resistance of Cry1Ab-selected Asian corn borer to other Cry toxins. Journal of Applied Entomology, 134(5), 429-438. https://doi.org/10.1111/j.1439-0418.2010.01517.x

The Asian corn borer, Ostrinia furnacalis (Guene´e) (Lepidoptera: Crambidae), is the most important insect pest of maize in China. Despite the proven track record of biotech Bacillus thuringiensis (Bt) maize to provide an effective means to control l... Read More about Cross-resistance of Cry1Ab-selected Asian corn borer to other Cry toxins.

Novel fusion proteins based on recombinant lectins for delivery of a cytotoxic peptide specifically to cancer cells
Thesis
Mohammed, S. Novel fusion proteins based on recombinant lectins for delivery of a cytotoxic peptide specifically to cancer cells. (Thesis). University of Salford

One of the most common post-translational modifications is covalent attachment of carbohydrates to proteins. At the cell surface, molecular recognition events involved in cancer metastasis are mediated by sugar moieties of glycoproteins. Evidence fro... Read More about Novel fusion proteins based on recombinant lectins for delivery of a cytotoxic peptide specifically to cancer cells.

Biochemical characteristics and antimicrobial potential of seed and nut oils against Staphylococcus aureus
Thesis
Yangomodou, O. (in press). Biochemical characteristics and antimicrobial potential of seed and nut oils against Staphylococcus aureus. (Thesis). University of Salford

The antibacterial activities of oils and extracts from walnut, cashew and pumpkin were investigated on methicillin resistant and susceptible strain MRSA 252 and S. aureus ATCC 6538 using the disc agar diffusion technique. Results revealed that the te... Read More about Biochemical characteristics and antimicrobial potential of seed and nut oils against Staphylococcus aureus.

Expression and characterization of recombinant human NEIL3 from Escherichia coli
Thesis
Albelazi, M. (in press). Expression and characterization of recombinant human NEIL3 from Escherichia coli. (Thesis). University of Salford

The DNA glycosylase NEIL3 is one of a family of proteins that release oxidized bases from DNA, thereby initiating base excision repair. NEIL3 gene expression is normally tightly regulated and expressed only in certain rapidly dividing cells, however,... Read More about Expression and characterization of recombinant human NEIL3 from Escherichia coli.