Distribution and clinical significance of heparan sulfate proteoglycans in ovarian cancer (2004)
Journal Article
Davies, E., Blackhall, F., Shanks, J., David, G., McGown, A., Swindell, R., …Jayson, G. (2004). Distribution and clinical significance of heparan sulfate proteoglycans in ovarian cancer. Clinical Cancer Research, 10(15), 5178-5186. https://doi.org/10.1158/1078-0432.CCR-03-0103

Purpose: Heparan sulfate proteoglycans have been implicated in cancer cell growth, invasion, metastasis, and angiogenesis. This study was designed to compare their expression in normal ovary and ovarian tumors and then to examine their prognostic sig... Read More about Distribution and clinical significance of heparan sulfate proteoglycans in ovarian cancer.

Asymmetric alkylation of diarylmethane derivatives. Improved results using methoxyethoxy substituent (2004)
Journal Article
Wilkinson, J., Rossington, S., Leonard, J., & Hussain, N. (2004). Asymmetric alkylation of diarylmethane derivatives. Improved results using methoxyethoxy substituent. Tetrahedron Letters, 45(28), 5481-5483. https://doi.org/10.1016/j.tetlet.2004.05.058

Alkylation of 2-methoxyethoxyphenyl phenyl methane using sec-BuLi and (−)-sparteine has been carried out in excellent yields and up to 94% ee. The best results were obtained in allylation reactions but methylation, ethylation, benzylation and trimeth... Read More about Asymmetric alkylation of diarylmethane derivatives. Improved results using methoxyethoxy substituent.

Nematode Aminopeptidases (2004)
Book Chapter
Brooks, D., & Isaac, R. (2004). Nematode Aminopeptidases. In N. Hooper, & U. Lendeckel (Eds.), Aminopeptidases in Biology and Disease (309-329). New York: Springer

The free-living nematode Caenorhabditis elegans has proven to be an excellent model organism for studying animal development and neurobiology. Analysis of the fully sequenced genome of C. elegans predicts that there are ~19,000 genes, of which ~ 2% a... Read More about Nematode Aminopeptidases.

Asymmetric alkylation of diphenylmethane derivatives using (-)-sparteine (2004)
Journal Article
Wilkinson, J., Rossington, S., Leonard, J., & Hussain, N. (2004). Asymmetric alkylation of diphenylmethane derivatives using (-)-sparteine. Tetrahedron Letters, 45(6), 1191-1193. https://doi.org/10.1016/j.tetlet.2003.11.138

Alkylation of 2-oxygenated diphenylmethane derivatives using sec-butyllithium and (−)-sparteine gave enantiomeric excesses of up to 60% with allyl bromide but alkylations with methyl electrophiles were poorly selective. When compounds with a free hyd... Read More about Asymmetric alkylation of diphenylmethane derivatives using (-)-sparteine.

The major human AP endonuclease (Ape1) is involved in the nucleotide incision repair pathway (2004)
Journal Article
Gros, L., Ishchenko, A., Ide, H., Elder, R., & Saparbaev, M. (2004). The major human AP endonuclease (Ape1) is involved in the nucleotide incision repair pathway. Nucleic Acids Research, 32(1), 73-81. https://doi.org/10.1093/nar/gkh165

In nucleotide incision repair (NIR), an endonuclease nicks oxidatively damaged DNA in a DNA glycosylase-independent manner, providing the correct ends for DNA synthesis coupled to the repair of the remaining 5'-dangling modified nucleotide. This mech... Read More about The major human AP endonuclease (Ape1) is involved in the nucleotide incision repair pathway.

Diblock polyampholytes grafted onto spherical particles : Monte Carlo simulation and lattice mean-field theory (2004)
Journal Article
Akinchina, A., Shusharina, N., & Linse, P. (2004). Diblock polyampholytes grafted onto spherical particles : Monte Carlo simulation and lattice mean-field theory. Langmuir, 20(23), 10351-10360. https://doi.org/10.1021/la0490386

Spherical brushes composed of diblock polyampholytes (diblock copolymers with oppositely charged blocks) grafted onto solid spherical particles in aqueous solution are investigated by using the primitive model solved with Monte Carlo simulations an... Read More about Diblock polyampholytes grafted onto spherical particles : Monte Carlo simulation and lattice mean-field theory.