Outputs (26)

Structural requirements for the interaction of combretastatins with tubulin: how important is the trimethoxy unit? (2003)
Journal Article
Gaukroger, K., Hadfield, J., Lawrence, N., Nolan, S., & McGown, A. (2003). Structural requirements for the interaction of combretastatins with tubulin: how important is the trimethoxy unit?. Organic and Biomolecular Chemistry, 1(17), 3033-3037. https://doi.org/10.1039/b306878a

A series of combretastatins possessing both a trimethoxy unit and other substituents on ring A has been synthesised and tested for cytotoxicity and their ability to interact with the protein tubulin. All previous studies have indicated that the trime... Read More about Structural requirements for the interaction of combretastatins with tubulin: how important is the trimethoxy unit?.

Structural requirements for the interaction of combretastatins with tubulin: how important is the trimethoxy unit? (2003)
Journal Article
Gaukroger, K., Hadfield, J., Lawrence, N., Nolan, S., & McGown, A. (2003). Structural requirements for the interaction of combretastatins with tubulin: how important is the trimethoxy unit?. Organic and Biomolecular Chemistry, 1(17), 3033-3037. https://doi.org/10.1039/b306878a

A series of combretastatins possessing both a trimethoxy unit and other substituents on ring A has been synthesised and tested for cytotoxicity and their ability to interact with the protein tubulin. All previous studies have indicated that the trime... Read More about Structural requirements for the interaction of combretastatins with tubulin: how important is the trimethoxy unit?.

Novel syntheses of cis and trans isomers of combretastatin A-4 (2001)
Journal Article
Gaukroger, K., Hadfield, J., Hepworth, L., Lawrence, N., & McGown, A. (2001). Novel syntheses of cis and trans isomers of combretastatin A-4. Journal of Organic Chemistry, 66(24), 8135-8138. https://doi.org/10.1021/jo015959z

A high-yielding, two-step stereoselective synthesis of the anticancer drug (Z)-combretastatin A-4 (1) has been devised. The method uses the Perkin condensation of 3,4,5-trimethoxyphenylacetic acid and 3-hydroxy-4-methoxybenzaldehyde followed by decar... Read More about Novel syntheses of cis and trans isomers of combretastatin A-4.

Novel syntheses of cis and trans isomers of combretastatin A-4 (2001)
Journal Article
Gaukroger, K., Hadfield, J., Hepworth, L., Lawrence, N., & McGown, A. (2001). Novel syntheses of cis and trans isomers of combretastatin A-4. Journal of Organic Chemistry, 66(24), 8135-8138. https://doi.org/10.1021/jo015959z

A high-yielding, two-step stereoselective synthesis of the anticancer drug (Z)-combretastatin A-4 (1) has been devised. The method uses the Perkin condensation of 3,4,5-trimethoxyphenylacetic acid and 3-hydroxy-4-methoxybenzaldehyde followed by decar... Read More about Novel syntheses of cis and trans isomers of combretastatin A-4.

Linked parallel synthesis and MTT bioassay screening of substituted chalcones (2001)
Journal Article
Lawrence, N., Rennison, D., McGown, A., Ducki, S., Gul, L., Hadfield, J., & Khan, N. (2001). Linked parallel synthesis and MTT bioassay screening of substituted chalcones. Journal of Combinatorial Chemistry, 3(5), 421-426. https://doi.org/10.1021/cc000075z

A 644-membered library of chalcones was prepared by parallel synthesis using the Claisen-Schmidt base-catalyzed aldol condensation of substituted acetophenones and benzaldehydes. The cytotoxicity of these chalcones was conveniently determined upon th... Read More about Linked parallel synthesis and MTT bioassay screening of substituted chalcones.

Linked parallel synthesis and MTT bioassay screening of substituted chalcones (2001)
Journal Article
Lawrence, N., Rennison, D., McGown, A., Ducki, S., Gul, L., Hadfield, J., & Khan, N. (2001). Linked parallel synthesis and MTT bioassay screening of substituted chalcones. Journal of Combinatorial Chemistry, 3(5), 421-426. https://doi.org/10.1021/cc000075z

A 644-membered library of chalcones was prepared by parallel synthesis using the Claisen-Schmidt base-catalyzed aldol condensation of substituted acetophenones and benzaldehydes. The cytotoxicity of these chalcones was conveniently determined upon th... Read More about Linked parallel synthesis and MTT bioassay screening of substituted chalcones.