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Synthesis and photophysical properties of meso‐aminophenyl-substituted heptamethine dyes as potential leads to new contrast agents (2019)
Journal Article
Okoh, O., Critchley, M., Bisby, R., Lawrence, C., Wainwright, M., & Smith, R. (2019). Synthesis and photophysical properties of meso‐aminophenyl-substituted heptamethine dyes as potential leads to new contrast agents. Coloration Technology, 135(4), 305-311. https://doi.org/10.1111/cote.12403

The series of rigid meso‐aminophenyl‐substituted heptamethine dyes presented herein exhibit surprising fluorescence properties, demonstrating larger Stokes shifts when compared with both structurally similar rigid meso‐chlorophenyl and linear heptame... Read More about Synthesis and photophysical properties of meso‐aminophenyl-substituted heptamethine dyes as potential leads to new contrast agents.

Modulation of antimalarial activity at a putative bisquinoline receptor in vivo using fluorinated bisquinolines (2017)
Journal Article

Antimalarials can interact with heme covalently, by π⋅⋅⋅π interactions or by hydrogen bonding. Consequently, the prototropy of 4‐aminoquinolines and quinoline methanols was investigated by using quantum mechanics. Calculations showed mefloquine proto... Read More about Modulation of antimalarial activity at a putative bisquinoline receptor in vivo using fluorinated bisquinolines.

New Approaches to Photodynamic Therapy from Type I, II and III to Type IV Using One or More Photons (2017)
Journal Article
Scherer, K., Bisby, R., Botchway, S., & Parker, A. (2017). New Approaches to Photodynamic Therapy from Type I, II and III to Type IV Using One or More Photons. Anti-Cancer Agents in Medicinal Chemistry, 17(2), 171-189. https://doi.org/10.2174/1871520616666160513131723

Photodynamic therapy (PDT) is an alternative cancer treatment to conventional surgery, radiotherapy and chemotherapy. It is based on activating a drug with light that triggers the generation of cytotoxic species that promote tumour cell killing. At p... Read More about New Approaches to Photodynamic Therapy from Type I, II and III to Type IV Using One or More Photons.

Three-dimensional imaging and uptake of the anticancer drug combretastatin in cell spheroids and photoisomerization in gels with multiphoton excitation (2015)
Journal Article

The uptake of E-combretastatins, potential pro-drugs of the anticancer Z-isomers, into multicellular spheroids has been imaged by intrinsic fluorescence in three dimensions using two-photon excited fluorescence lifetime imaging with 625 nm ultrafast... Read More about Three-dimensional imaging and uptake of the anticancer drug combretastatin in cell spheroids and photoisomerization in gels with multiphoton excitation.

A series of flexible design adaptations to the Nikon E-C1 and E-C2 confocal microscope systems for UV, multiphoton and FLIM imaging (2015)
Journal Article
Botchway, S., Scherer, K., Hook, S., Stubbs, C., Weston, E., Bisby, R., & Parker, A. (2015). A series of flexible design adaptations to the Nikon E-C1 and E-C2 confocal microscope systems for UV, multiphoton and FLIM imaging. Journal of Microscopy, 258(1), 68-78. https://doi.org/10.1111/jmi.12218

Multiphoton microscopy in combination with Fluorescence Lifetime Imaging Microscopy (FLIM) is now a key technique in biomedical and life-science research for live cell and whole animal imaging providing several advantages over the one photon confocal... Read More about A series of flexible design adaptations to the Nikon E-C1 and E-C2 confocal microscope systems for UV, multiphoton and FLIM imaging.

Anticancer phototherapy using activation of E-combretastatins by two-photon–induced isomerization (2014)
Journal Article
Hadfield, J., Bisby, R., Scherer, K., Botchway, S., & Parker, A. (2014). Anticancer phototherapy using activation of E-combretastatins by two-photon–induced isomerization. Journal of Biomedical Optics, 20(5), 1004-1. https://doi.org/10.1117/1.JBO.20.5.051004

The photoisomerization of relatively nontoxic E-combretastatins to clinically active Z-isomers is
shown to occur in solution through both one- and two-photon excitations at 340 and 625 nm, respectively.
The photoisomerization is also demonstrated t... Read More about Anticancer phototherapy using activation of E-combretastatins by two-photon–induced isomerization.

Ultrafast vibrational spectroscopic Studies on the photoionization of the α-Tocopherol analogue Trolox C (2014)
Journal Article

The initial events after photoexcitation and photoionization of α-tocopherol (vitamin E) and the analogue Trolox C have been studied by femtosecond stimulated Raman spectroscopy, transient absorption spectroscopy and time-resolved infrared spectrosco... Read More about Ultrafast vibrational spectroscopic Studies on the photoionization of the α-Tocopherol analogue Trolox C.

Spectroscopy and fluorescence lifetime imaging in live cells of a cyano-substituted combretastatin (2014)
Journal Article
combretastatin. Biomedical Spectroscopy and Imaging, 3, 211-218. https://doi.org/10.3233/BSI-140067

Fluorescence lifetime imaging has been used to observe the real-time uptake in live mammalian cells of a
combretastatin-type drug analogue that is a substituted stilbene with a cyano group at the bridging olefinic bond. Fluorescence spectra in a ran... Read More about Spectroscopy and fluorescence lifetime imaging in live cells of a cyano-substituted combretastatin.

Spectroscopy and fluorescence lifetime imaging in live cells of a cyano-substituted combretastatin (2014)
Journal Article
combretastatin. Biomedical Spectroscopy and Imaging, 3, 211-218. https://doi.org/10.3233/BSI-140067

Fluorescence lifetime imaging has been used to observe the real-time uptake in live mammalian cells of a
combretastatin-type drug analogue that is a substituted stilbene with a cyano group at the bridging olefinic bond. Fluorescence spectra in a ran... Read More about Spectroscopy and fluorescence lifetime imaging in live cells of a cyano-substituted combretastatin.

Promising near-infrared non-targeted probes: benzothiazole heptamethine cyanine dyes (2014)
Journal Article
Okoh, O., Bisby, R., Lawrence, C., Rolph, C., & Smith, R. (2014). Promising near-infrared non-targeted probes: benzothiazole heptamethine cyanine dyes. Journal of Sulfur Chemistry, 35(1), 42-56. https://doi.org/10.1080/17415993.2013.778258

A series of benzothiazole heptamethine cyanine dyes have been synthesized and their photophysical properties evaluated in relation to their structural features. These have been compared against two classical probes of this type: Indocyanine Green (IG... Read More about Promising near-infrared non-targeted probes: benzothiazole heptamethine cyanine dyes.