School of Science, Engineering & Environment

A novel approach to the analysis of spin-trapped free radicals using dimethyl sulfoxide and Gas Chromatography – Mass Spectrometry (GC-MS) with both solvent extraction and headspace solid phase microextraction (HS-SPME) (2021)
Journal Article
Mishra, S., Manzoor, K., Zafar, M., & Podmore, I. (2021). A novel approach to the analysis of spin-trapped free radicals using dimethyl sulfoxide and Gas Chromatography – Mass Spectrometry (GC-MS) with both solvent extraction and headspace solid phase microextraction (HS-SPME). Free Radical Research, 55(5), 569-578. https://doi.org/10.1080/10715762.2021.1980563

In this study, we have utilized a novel strategy based upon the use of dimethyl sulfoxide (DMSO) and gas chromatography-mass spectrometry (GC-MS)for the detectionand identification ofspin-trapped free radicals. Hydroxymethyl (.CH2OH) radicals, genera... Read More about A novel approach to the analysis of spin-trapped free radicals using dimethyl sulfoxide and Gas Chromatography – Mass Spectrometry (GC-MS) with both solvent extraction and headspace solid phase microextraction (HS-SPME).

The detection and characterisation of novel alkyl spin-adducts of PBN and its derivatives using capillary gas chromatography coupled to electron-ionisation mass spectrometry (2021)
Thesis
Zafar, M. (2021). The detection and characterisation of novel alkyl spin-adducts of PBN and its derivatives using capillary gas chromatography coupled to electron-ionisation mass spectrometry. (Thesis). University of Salford

Free radical induced oxidative stress has been reported to be involved in several diseases such as diabetes mellitus, neurodegenerative disorders, cardiovascular diseases (atherosclerosis and hypertension), respiratory diseases (asthma), cataract dev... Read More about The detection and characterisation of novel alkyl spin-adducts of PBN and its derivatives using capillary gas chromatography coupled to electron-ionisation mass spectrometry.

Detection and identification of ethanal-derived spin-trapped free radicals using headspace thermal desorption gas chromatography-mass spectrometry (TD-GC-MS) (2020)
Journal Article
Manzoor, K., Mishra, S., & Podmore, I. (2020). Detection and identification of ethanal-derived spin-trapped free radicals using headspace thermal desorption gas chromatography-mass spectrometry (TD-GC-MS). Free Radical Research, 54(10), 745-755. https://doi.org/10.1080/10715762.2020.1841183

In this study, we demonstrate a novel approach to the detection and identification of the products of spin-trapped free radicals. Hydroxyl free radicals were generated by Fenton-based chemistry in the presence of ethanal and the spin-trapping agent... Read More about Detection and identification of ethanal-derived spin-trapped free radicals using headspace thermal desorption gas chromatography-mass spectrometry (TD-GC-MS).

Detection and analysis of spin trapped radical adducts using thermal desorption gas chromatography mass spectrometry (TD-GC-MS) (2018)
Thesis
Manzoor, K. (2018). Detection and analysis of spin trapped radical adducts using thermal desorption gas chromatography mass spectrometry (TD-GC-MS). (Thesis). University of Salford

Certain oxygen free radicals are produced constantly in cells by metabolism and exogenous agents. Some, such as the hydroxyl radical, may react with various biomolecules like DNA, lipids or proteins, and thus be involved in the pathogenesis of var... Read More about Detection and analysis of spin trapped radical adducts using thermal desorption gas chromatography mass spectrometry (TD-GC-MS).

Solid phase microextraction (SPME) method development in analysis of volatile organic compounds (VOCs) as potential biomarkers of cancer (2015)
Journal Article
Schmidt, K., & Podmore, I. (2015). Solid phase microextraction (SPME) method development in analysis of volatile organic compounds (VOCs) as potential biomarkers of cancer. Journal of Molecular Biomarkers & Diagnosis, 6(6), https://doi.org/10.4172/2155-9929.1000253

The analysis of volatile organic compounds [VOCs] is an attractive approach to the discovery of potential cancer biomarkers due to its non-invasive nature and potential low costs of sampling and analysis. Solid phase microextraction [SPME] is one of... Read More about Solid phase microextraction (SPME) method development in analysis of volatile organic compounds (VOCs) as potential biomarkers of cancer.

Current challenges in volatile organic compounds analysis as potential biomarkers of cancer (2015)
Journal Article
Schmidt, K., & Podmore, I. (2015). Current challenges in volatile organic compounds analysis as potential biomarkers of cancer. Journal of Biomarkers (Online), 2015(981458), https://doi.org/10.1155/2015/981458

An early diagnosis and appropriate treatment are crucial in reducing mortality among people suffering from cancer. There is a lack of characteristic early clinical symptoms in most forms of cancer, which highlights the importance of investigating new... Read More about Current challenges in volatile organic compounds analysis as potential biomarkers of cancer.

Cellular biochemical and experimental therapeutic studies of L-glutamine and L-asparagine depletion for paediatric sarcoma cells (2011)
Thesis
Allsup, J. Cellular biochemical and experimental therapeutic studies of L-glutamine and L-asparagine depletion for paediatric sarcoma cells. (Thesis). University of Salford

The aim of this project was to investigate the cellular biochemical and experimental therapeutic effects of L-glutamine (gin) and L-asparagine (asn) depletion for paediatric sarcoma cells. The work presented in this thesis describes preclinical stud... Read More about Cellular biochemical and experimental therapeutic studies of L-glutamine and L-asparagine depletion for paediatric sarcoma cells.

Biochemical changes and cytotoxicity associated with methionine depletion in paediatric central nervous system tumour cell lines (2009)
Journal Article
Najim, N., Podmore, I., Mcgown, A., & Estlin, E. (2009). Biochemical changes and cytotoxicity associated with methionine depletion in paediatric central nervous system tumour cell lines. Anticancer Research, 29(8), 2971-2976

The aim of this study was to investigate the importance of the extent and duration of methionine depletion as a cause of cytotoxicity for CNS tumour cell lines, and also to investigate the associated in vitro cellular biochemical responses. MATERIALS... Read More about Biochemical changes and cytotoxicity associated with methionine depletion in paediatric central nervous system tumour cell lines.

Outputs (23)