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Outputs (41)

Enhanced Activity and Stability of an Acetyl Xylan Esterase in Hydrophilic Alcohols through Site-Directed Mutagenesis (2023)
Journal Article
Madubuike, H., & Ferry, N. (in press). Enhanced Activity and Stability of an Acetyl Xylan Esterase in Hydrophilic Alcohols through Site-Directed Mutagenesis. Molecules, 28(21), 7393. https://doi.org/10.3390/molecules28217393

Current demands for the development of suitable biocatalysts showing high process performance is stimulated by the need to replace current chemical synthesis with cleaner alternatives. A drawback to the use of biocatalysts for unique applications is... Read More about Enhanced Activity and Stability of an Acetyl Xylan Esterase in Hydrophilic Alcohols through Site-Directed Mutagenesis.

Characterisation and biochemical activity testing of CE1 and GH78 family enzymes; towards improved glycosyl hydrolases for the production of biofuel and biobased products (2022)
Thesis
Austin, S. Characterisation and biochemical activity testing of CE1 and GH78 family enzymes; towards improved glycosyl hydrolases for the production of biofuel and biobased products. (Thesis). University of Salford

Traditional chemical industries currently involved in the manufacturing and processing of high-value molecules used in the food, pharmaceutical and biofuel sector rely heavily on chemicals derived from fossil fuels such as crude oil. Fossil fuels rep... Read More about Characterisation and biochemical activity testing of CE1 and GH78 family enzymes; towards improved glycosyl hydrolases for the production of biofuel and biobased products.

Identification and characterisation of lignin degrading bacteria and enzymes from larval guts of the African Palm Weevil (Rhynchophorus phoenicis) (2022)
Thesis
larval guts of the African Palm Weevil (Rhynchophorus phoenicis). (Thesis). University of Salford

As developing economies continue to grow, the world’s demand for energy which currently stands at 84MB (million barrels oil) per day is projected to rise to 116 MB per day by the year 2030. The need to meet this continuous rise in demand for energy w... Read More about Identification and characterisation of lignin degrading bacteria and enzymes from larval guts of the African Palm Weevil (Rhynchophorus phoenicis).

Bioprospecting novel hemicellulases from the gut microbiota of the common black slug (Arion ater) (2022)
Thesis
Madubuike, H. Bioprospecting novel hemicellulases from the gut microbiota of the common black slug (Arion ater). (Thesis). University of Salford

The attendant effect of continuous fossil use on the environment and energy security has prompted the search for a suitable energy alternative devoid of negative characteristics. Lignocellulose-biomass (LCB) is a renewable source of carbon for the de... Read More about Bioprospecting novel hemicellulases from the gut microbiota of the common black slug (Arion ater).

Characterisation of a Novel Acetyl Xylan Esterase (BaAXE) screened from the Gut Microbiota of the Common Black Slug (Arion ater) (2022)
Journal Article
Madubuike, H., & Ferry, N. (2022). Characterisation of a Novel Acetyl Xylan Esterase (BaAXE) screened from the Gut Microbiota of the Common Black Slug (Arion ater). Molecules, 27(9), 2999. https://doi.org/10.3390/molecules27092999

Acetyl xylan esterases (AXEs) are enzymes capable of hydrolysing the acetyl bonds in acetylated xylan, allowing for enhanced activity of backbone-depolymerizing enzymes. Bioprospecting novel AXE is essential in designing enzyme cocktails with desired... Read More about Characterisation of a Novel Acetyl Xylan Esterase (BaAXE) screened from the Gut Microbiota of the Common Black Slug (Arion ater).

Fungal microbiomes are determined by host phylogeny and exhibit widespread associations with the bacterial microbiome (2021)
Journal Article
Harrison, X., McDevitt, A., Dunn, J., Grifftihs, S., Benvenuto, C., Birtles, R., …Antwis, R. (2021). Fungal microbiomes are determined by host phylogeny and exhibit widespread associations with the bacterial microbiome. Proceedings of the Royal Society B: Biological Sciences, 288(1957), 20210552. https://doi.org/10.1098/rspb.2021.0552

Interactions between hosts and their resident microbial communities are a fundamental component of fitness for both agents. Though recent research has highlighted the importance of interactions between animals and their bacterial communities, compara... Read More about Fungal microbiomes are determined by host phylogeny and exhibit widespread associations with the bacterial microbiome.

Characterization of sialic acid affinity of the binding domain of mistletoe lectin isoform one (2021)
Journal Article
Mohammed, S., & Ferry, N. (2021). Characterization of sialic acid affinity of the binding domain of mistletoe lectin isoform one. International Journal of Molecular Sciences, 22(15), e8284. https://doi.org/10.3390/ijms22158284

Sialic acid (Sia) is considered as one of the most important biomolecules of life since its derivatives and terminal orientations on cell membranes and macromolecules play a major role in many biological and pathological processes. To date, there is... Read More about Characterization of sialic acid affinity of the binding domain of mistletoe lectin isoform one.

Fungal microbiomes are determined by host phylogeny and exhibit widespread associations with the bacterial microbiome (2021)
Other
Harrison, X., McDevitt, A., Dunn, J., Griffiths, S., Benvenuto, C., Birtles, R., …Antwis, R. (2021). Fungal microbiomes are determined by host phylogeny and exhibit widespread associations with the bacterial microbiome

Interactions between hosts and their resident microbial communities are a fundamental component of fitness for both agents. Though recent research has highlighted the importance of interactions between animals and their bacterial communities, compara... Read More about Fungal microbiomes are determined by host phylogeny and exhibit widespread associations with the bacterial microbiome.

Circular and linear : a tale of aptamer selection for the activation of SIRT1 to induce death in cancer cells (2020)
Journal Article
Al-Sudani, B., Ragazzon-Smith, A., Aziz, A., Alansari, R., Ferry, N., Krstic- Demonacos, M., & Ragazzon, P. (2020). Circular and linear : a tale of aptamer selection for the activation of SIRT1 to induce death in cancer cells. RSC Advances, 10(73), 45008-45018. https://doi.org/10.1039/D0RA07857C

It is a challenge to select the right target to treat conditions without affecting non-diseased cells. Cancer belongs to the top 10 causes of death in the world and it remains difficult to treat. Amongst cancer emerging targets, silent information re... Read More about Circular and linear : a tale of aptamer selection for the activation of SIRT1 to induce death in cancer cells.

Metagenomic analysis of the gut microbiome of the common black slug Arion ater in search of novel lignocellulose degrading enzymes (2017)
Journal Article
Joynson, R., Pritchard, L., Ekenakema, O., & Ferry, N. (2017). Metagenomic analysis of the gut microbiome of the common black slug Arion ater in search of novel lignocellulose degrading enzymes. Frontiers in Microbiology, 8, 2181. https://doi.org/10.3389/fmicb.2017.02181

Some eukaryotes are able to gain access to well-protected carbon sources in plant biomass by exploiting microorganisms in the environment or harbored in their digestive system. One is the land pulmonate Arion ater, which takes advantage of a gut micr... Read More about Metagenomic analysis of the gut microbiome of the common black slug Arion ater in search of novel lignocellulose degrading enzymes.