Colorectal cancer (CRC) is one of the most common cancers in the UK and medulloblastoma is a common cancer found in children. While there has been a progressive improvement in treatment outcomes, success has been marred by drug resistance and severe... Read More about Overcoming drug resistance: targeting the BCL-2 family and the long non-coding RNA HCP5 in medulloblastoma and colorectal cancer.
Outputs (15033)
Investigating small extracellular vesicle miRNA as biomarkers for Alzheimer’s disease (2023)
Thesis
Alzheimer’s disease (AD) is the leading cause of dementia, a syndrome impacting over 900,000 people in the UK alone. There are currently no disease modifying treatments for AD, which is largely attributable to the heterogenous basis of the disease wh... Read More about Investigating small extracellular vesicle miRNA as biomarkers for Alzheimer’s disease.
An investigation of energy saving behaviour for residential buildings in Nigeria (2023)
Thesis
Threats of climate change, global warming and uncertainty about future energy prices have sparked a global discussion about energy efficiency, particularly energy saving behaviour in residential buildings. Numerous challenges have been faced in achie... Read More about An investigation of energy saving behaviour for residential buildings in Nigeria.
The Effects of Salt Precipitation During CO2 Injection into Deep Saline Aquifer and Remediation Techniques (2023)
Thesis
The by-products of combustion from the utilisation of fossil fuels for energy generation are a source of greenhouse gas emissions, mainly Carbon dioxide (CO2). This has been attributed to climate change because of global warming. Carbon capture and s... Read More about The Effects of Salt Precipitation During CO2 Injection into Deep Saline Aquifer and Remediation Techniques.
The effects of anthracyclines on calcium handling and contractility in sheep ventricular myocytes; role of oxidative stress (2023)
Thesis
Anthracyclines such as doxorubicin (DOX) and daunorubicin (DAUN) are effective chemotherapeutics and contribute to improved cancer survival rates in children and adults. However, anthracyclines exhibit acute and chronic cardiotoxicity which can produ... Read More about The effects of anthracyclines on calcium handling and contractility in sheep ventricular myocytes; role of oxidative stress.
Decomposed vibro-acoustic frequency response functions for the prediction of radiated sound (2023)
Thesis
There are several methods employed to conduct analysis of vibrations in structures. These
methods can be applied to various problems caused by vibrations, such as external noise, and
also to monitor the behavior of the source or structure which is... Read More about Decomposed vibro-acoustic frequency response functions for the prediction of radiated sound.
Real Time Crime Prediction Using Social Media (2023)
Thesis
There is no doubt that crime is on the increase and has a detrimental influence on a nation's economy despite several attempts of studies on crime prediction to minimise crime rates. Historically, data mining techniques for crime prediction models of... Read More about Real Time Crime Prediction Using Social Media.
The landscape of tolerated genetic variation in humans and primates. (2023)
Journal Article
Personalized genome sequencing has revealed millions of genetic differences between individuals, but our understanding of their clinical relevance remains largely incomplete. To systematically decipher the effects of human genetic variants, we obtain... Read More about The landscape of tolerated genetic variation in humans and primates..
Design, Dimensional Synthesis and Evaluation of a Novel Two-Degrees-of-Freedom Spherical Remote Center of Motion Mechanism for Minimally Invasive Surgery (2023)
Journal Article
Li, J., Wang, J., Zhao, J., & Wei, G. (in press). Design, Dimensional Synthesis and Evaluation of a Novel Two-Degrees-of-Freedom Spherical Remote Center of Motion Mechanism for Minimally Invasive Surgery. Journal of Mechanisms and Robotics, 1-38. https://doi.org/10.1115/1.4062673With the development of minimally invasive surgery (MIS) technology, higher requirements are put forward for the performance of remote center of motion (RCM) manipulator. This paper presents the conceptual design of a novel two degrees of freedom (2-... Read More about Design, Dimensional Synthesis and Evaluation of a Novel Two-Degrees-of-Freedom Spherical Remote Center of Motion Mechanism for Minimally Invasive Surgery.
Mechanisms of low susceptibility to the disinfectant benzalkonium chloride in a multidrug-resistant environmental isolate of Aeromonas hydrophila (2023)
Journal Article
Chacón, L., Kuropka, B., González-Tortuero, E., Schreiber, F., Rojas-Jiménez, K., & Rodríguez-Rojas, A. (in press). Mechanisms of low susceptibility to the disinfectant benzalkonium chloride in a multidrug-resistant environmental isolate of Aeromonas hydrophila. Frontiers in Microbiology, 14, 1180128. https://doi.org/10.3389/fmicb.2023.1180128Excessive discharge of quaternary ammonium disinfectants such as benzalkonium chloride (BAC) into aquatic systems can trigger several physiological responses in environmental microorganisms. In this study, we isolated a less-susceptible strain of Aer... Read More about Mechanisms of low susceptibility to the disinfectant benzalkonium chloride in a multidrug-resistant environmental isolate of Aeromonas hydrophila.