S Eldakhakhny
Human papillomavirus E7 induces p63 expression to modulate DNA damage response
Eldakhakhny, S; Zhou, Q; Crosbie, EJ; Sayan, BS
Abstract
Cervical cancer is the third most common malignancy diagnosed in women worldwide. The major aetiological factor underlying the malignant transformation of cervical cells is the persistent infection with high-risk human papillomaviruses (HR-HPV), with more than 99% of cases expressing viral sequences. Here, we report a previously unknown mechanism driven by high-risk human papillomavirus E7 protein to modulate response to DNA damage in cervical cancer cells. Our data shows that HR-HPV E7 oncoprotein induces the transcription of the p53-family member p63, which modulates DNA damage response pathways, to facilitate repair of DNA damage. Based on our findings, we proposed a model, where HR-HPV could interfere with the sensitivity of transformed cells to radiation therapy by modulating DNA damage repair efficiency. Importantly, we have shown for the first time a critical role for p63 in response to DNA damage in cervical cancer cells.
Citation
Eldakhakhny, S., Zhou, Q., Crosbie, E., & Sayan, B. (2018). Human papillomavirus E7 induces p63 expression to modulate DNA damage response. Cell Death and Disease, 9, https://doi.org/10.1038/s41419-017-0149-6
Journal Article Type | Article |
---|---|
Acceptance Date | Nov 15, 2017 |
Online Publication Date | Jan 26, 2018 |
Publication Date | Jan 26, 2018 |
Deposit Date | Feb 14, 2023 |
Publicly Available Date | Feb 14, 2023 |
Journal | Cell Death and Disease |
Publisher | Nature Publishing Group |
Volume | 9 |
DOI | https://doi.org/10.1038/s41419-017-0149-6 |
Publisher URL | https://doi.org/10.1038/s41419-017-0149-6 |
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http://creativecommons.org/licenses/by/4.0/
Publisher Licence URL
http://creativecommons.org/licenses/by/4.0/
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