Outcomes and care priorities for older people living with frailty and advanced chronic kidney disease: a multi-professional scoping review

Hurst, HE; Young, HL; Nixon, A; Brettle, AJ; Ormandy, P

Abstract

Background
The growing older population with advanced chronic kidney disease (ACKD stages 4-5) poses
a challenge for healthcare worldwide. The high prevalence of frailty and associated adverse
health outcomes highlights concerns for management and interventions specific to this
population.
Objectives
The aim was to objectively review the evidence relating to older people (>65years) living with
frailty and ACKD. More specifically how frailty is identified, what interventions have been
studied and what outcomes have been reported including outcomes important to patients,
families and carers.
Methods
A scoping review was undertaken following the PRISMA-Scr guidelines. Nine databases were
searched and a review team of five people followed a process using defined inclusion and
exclusion criteria. Data was then analysed to answer the specific questions of the review. The
World Health Organisation (WHO)’s International Classification of Functioning Disability and
Health (ICF) was used to map outcomes across the domains.
Results
A total of 90 studies were included. The most reported frailty measure was the Frailty
Phenotype. The most reported outcomes were mortality, hospitalisation and healthcare
utilisation. Health related quality of life was the most common patient reported outcome
measure. There were few intervention studies and limited evidence of patient and carer
perspectives.

Citation

Hurst, H., Young, H., Nixon, A., Brettle, A., & Ormandy, P. (2022). Outcomes and care priorities for older people living with frailty and advanced chronic kidney disease: a multi-professional scoping review. Age and ageing, 51(12), https://doi.org/10.1093/ageing/afac296

• Journal Article Type: Article
• Acceptance Date: Sep 13, 2022
• Online Publication Date: Dec 29, 2022
• Publication Date: Dec 29, 2022
• Deposit Date: Jan 9, 2023
• Publicly Available Date: Dec 30, 2023
• Journal: Age and Ageing
• Print ISSN: 0002-0729
• Electronic ISSN: 1468-2834
• Publisher: Oxford University Press
• Volume: 51
• Issue: 12
• DOI: https://doi.org/10.1093/ageing/afac296
• Publisher URL: https://doi.org/10.1093/ageing/afac296
• Additional Information: Additional Information : This is a pre-copyedited, author-produced version of an article accepted for publication in Age and Ageing following peer review. The version of record Helen Hurst, Hannah M L Young, Andrew C Nixon, Paula Ormandy, Alison Brettle, The scoping review author collaborative for outcomes and care priorities for older people with ACKD, Outcomes and care priorities for older people living with frailty and advanced chronic kidney disease: a multi-professional scoping review, Age and Ageing, Volume 51, Issue 12, December 2022, afac296 is available online at: https://doi.org/10.1093/ageing/afac296; Projects : Outcomes and care priorities for older people living with frailty and advanced chronic kidney disease: a multi-professional scoping review;Difficult Conversations Booklet: a resource for health professionals