Gait Alteration Due to Haemophilic Arthropathies in Patients with Moderate Haemophilia

Fouasson-Chailloux, Alban; Leboeuf, Fabien; Maugars, Yves; Trossaert, Marc; Menu, Pierre; Rannou, François; Vinatier, Claire; Guicheux, Jérome; Gross, Raphael; Dauty, Marc

Abstract

Some patients with moderate haemophilia (PWMH) report joint damage potentially responsible for gait disorders. Three-dimensional gait analysis (3DGA) is a relevant tool for the identification of complex musculoskeletal impairment. We performed an evaluation with 3DGA of 24 PWMH aged 44.3 ± 16.1 according to their joint status [Haemophilia Joint Health Score (HJHS) < 10 or HJHS ≥ 10] and assessed the correlation with the radiological and clinical parameters. Sixteen had HJHS < 10 (group 1) and eight had HJHS ≥ 10 (group 2). They were compared to 30 healthy subjects of a normative dataset. Both knee and ankle gait variable scores were increased in group 2 compared to the controls (p = 0.02 and p = 0.04, respectively). The PWMH of group 2 had a significant increase in their stance phase, double support duration, and stride width compared to the controls and group 1 (p < 0.01). Very low correlations were found for the ankle gait variable score with the ankle Pettersson sub-score (r2 = 0.250; p = 0.004) and ankle HJHS sub-score (r2 = 0.150; p = 0.04). For the knee, very low correlation was also found between the knee gait variable score and its HJHS sub-score (r2 = 0.290; p < 0.0001). Patients with moderate haemophilia presented a gait alteration in the case of poor lower limb joint status.

Citation

Fouasson-Chailloux, A., Leboeuf, F., Maugars, Y., Trossaert, M., Menu, P., Rannou, F., …Dauty, M. (2022). Gait Alteration Due to Haemophilic Arthropathies in Patients with Moderate Haemophilia. International Journal of Environmental Research and Public Health, 19(12), 7527. https://doi.org/10.3390/ijerph19127527

• Journal Article Type: Article
• Acceptance Date: Jun 18, 2022
• Online Publication Date: Jun 20, 2022
• Publication Date: Jun 20, 2022
• Deposit Date: Aug 12, 2022
• Publicly Available Date: Aug 12, 2022
• Journal: International Journal of Environmental Research and Public Health
• Publisher: MDPI
• Volume: 19
• Issue: 12
• Pages: 7527
• DOI: https://doi.org/10.3390/ijerph19127527
• Publisher URL: https://doi.org/10.3390/ijerph19127527
• Related Public URLs: https://europepmc.org/articles/PMC9223556