Computational simulation of rheological blood flow containing hybrid nanoparticles in an inclined catheterized artery with stenotic, aneurysmal and slip effects

Tripathi, J; Vasu, B; Beg, OA; Gorla, RSR; Kameswaran, PK

Abstract

Influenced by nano-drug delivery applications, the present article considers the collective
effects of hybrid biocompatible metallic nanoparticles (Silver and Copper), a stenosis and an aneurysm on
the unsteady blood flow characteristics in a catheterized tapered inclined artery. The non-Newtonian
Carreau fluid model is deployed to represent the hemorheological characteristics in the arterial region. A
modified Tiwari-Das volume fraction model is adopted for nanoscale effects. The permeability of the
arterial wall and the inclination of the diseased artery are taken into account. The nanoparticles are also
considered to have various shapes (bricks, cylinders, platelets, blades) and therefore the influence of
different shape parameters is discussed. The conservation equations for mass, linear momentum and energy
are normalized by employing suitable non-dimensional variables. The transformed equations with
associated boundary conditions are solved numerically using the FTCS method. Key hemodynamic
characteristics i.e. velocity, temperature, flow rate, wall shear stress (WSS) in stenotic and aneurysm region
for a particular critical height of the stenosis, are computed. Hybrid nanoparticles (Ag-Cu/Blood) accelerate
the axial flow and increase temperatures significantly compared with unitary nanoparticles (Ag/blood), at
both the stenosis and aneurysm segments. Axial velocity, temperature and flow rate are all enhanced with
greater nanoparticle shape factor. Axial velocity, temperature, wall shear stress and flow rate magnitudes
are always comparatively higher at the aneurysm region compared with the stenotic segment. The
simulations provide novel insights into the performance of different nanoparticle geometries and also
rheological behaviour in realistic nano-pharmaco-dynamic transport and percutaneous coronary
intervention (PCI).

Citation

Tripathi, J., Vasu, B., Beg, O., Gorla, R., & Kameswaran, P. (2021). Computational simulation of rheological blood flow containing hybrid nanoparticles in an inclined catheterized artery with stenotic, aneurysmal and slip effects. Computers in Biology and Medicine, 139, 105009. https://doi.org/10.1016/j.compbiomed.2021.105009

• Journal Article Type: Article
• Acceptance Date: Oct 29, 2021
• Online Publication Date: Nov 2, 2021
• Publication Date: Dec 1, 2021
• Deposit Date: Nov 1, 2021
• Publicly Available Date: Nov 2, 2022
• Journal: Computers in Biology and Medicine
• Print ISSN: 0010-4825
• Electronic ISSN: 1879-0534
• Publisher: Elsevier
• Volume: 139
• Pages: 105009
• DOI: https://doi.org/10.1016/j.compbiomed.2021.105009
• Publisher URL: https://doi.org/10.1016/j.compbiomed.2021.105009
• Related Public URLs: https://www.journals.elsevier.com/computers-in-biology-and-medicine
• Additional Information: Funders : Science and Engineering Research Board (SERB);Department of Science and Technology (DST);Government of India; Projects : Computational hemorheological nanofluid dynamics; Grant Number: ECR/2017/001053