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SnoRNAs and miRNAs networks underlying COVID-19 disease severity

Parray, A; Mir, FA; Doudin, A; Iskandarani, A; Danjuma, IMM; Kuni, RAT; Abdelmajid, A; Abdelhafez, I; Arif, R; Mulhim, M; Abukhattab, M; Dar, SR; Moustafa, A-EA; Elkord, E; Al Khal, AL; Elzouki, A-N; Cyprian, F

SnoRNAs and miRNAs networks underlying COVID-19 disease severity Thumbnail


Authors

A Parray

FA Mir

A Doudin

A Iskandarani

IMM Danjuma

RAT Kuni

A Abdelmajid

I Abdelhafez

R Arif

M Mulhim

M Abukhattab

SR Dar

A-EA Moustafa

E Elkord

AL Al Khal

A-N Elzouki

F Cyprian



Contributors

GA Sautto
Editor

RA Diotti
Editor

RB Abreu
Editor

Abstract

There is a lack of predictive markers for early and rapid identification of disease progression in COVID-19 patients. Our study aims at identifying microRNAs (miRNAs)/small nucleolar RNAs (snoRNAs) as potential biomarkers of COVID-19 severity. Using differential expression analysis of microarray data (n = 29), we identified hsa-miR-1246, ACA40, hsa-miR-4532, hsa-miR-145-5p, and ACA18 as the top five differentially expressed transcripts in severe versus asymptomatic, and ACA40, hsa-miR-3609, ENSG00000212378 (SNORD78), hsa-miR-1231, hsa-miR-885-3p as the most significant five in severe versus mild cases. Moreover, we found that white blood cell (WBC) count, absolute neutrophil count (ANC), neutrophil (%), lymphocyte (%), red blood cell (RBC) count, hemoglobin, hematocrit, D-Dimer, and albumin are significantly correlated with the identified differentially expressed miRNAs and snoRNAs. We report a unique miRNA and snoRNA profile that is associated with a higher risk of severity in a cohort of SARS-CoV-2 infected patients. Altogether, we present a differential expression analysis of COVID-19-associated microRNA (miRNA)/small nucleolar RNA (snoRNA) signature, highlighting their importance in SARS-CoV-2 infection.

Citation

Parray, A., Mir, F., Doudin, A., Iskandarani, A., Danjuma, I., Kuni, R., …Cyprian, F. (2021). SnoRNAs and miRNAs networks underlying COVID-19 disease severity. Vaccines, 9(10), e1056. https://doi.org/10.3390/vaccines9101056

Journal Article Type Article
Acceptance Date Sep 19, 2021
Publication Date Sep 23, 2021
Deposit Date Sep 27, 2021
Publicly Available Date Sep 27, 2021
Journal Vaccines
Publisher MDPI
Volume 9
Issue 10
Pages e1056
DOI https://doi.org/10.3390/vaccines9101056
Publisher URL https://doi.org/10.3390/vaccines9101056
Related Public URLs http://www.mdpi.com/journal/vaccines
Additional Information Additional Information : ** From MDPI via Jisc Publications Router ** Licence for this article: https://creativecommons.org/licenses/by/4.0/ **Journal IDs: eissn 2076-393X **History: published 23-09-2021; accepted 19-09-2021
Funders : Qatar University
Grant Number: QUST-1-CMED-2021-2

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