P25. Tolerance and diagnostic accuracy of myocardial scintigraphy with adenosine infusion, 6 min (standard) versus 3 min (abbreviated) protocol

Gopinath, G; Buscombe, JR; Naojee, S; Szczepura, K; Hilson, AJW

Abstract

Myocardial perfusion scintigraphy with adenosine is an effective and safe method for diagnosing coronary artery disease (CAD). Various reports suggest that a 3 min stress regime is as efficacious as a 6 min regime. The aim of the study was to study the tolerance and efficacy of these two regimes. Two hundred and eighty-one patients (100, 6 min; 181, 3 min) had adenosine stressed myocardial scintigraphy. Blood pressures, heart rate and ECG were recorded at baseline and during the test. Any symptoms (flushing, headache, chest pain, dyspnoea and neck pain) were also recorded throughout and for 5 min after the adenosine infusion. 117/281 patients (41.6%) reported side effects including flushing (33% in 3 min vs 45% 6 min, P<0.05), headache (12.7% vs 9%, not significant (NS)), chest pain (7% vs 10%, NS), dyspnoea (7.7% vs 13%, NS), and neck pain (4.9% vs 7%). Significant ECG changes occurred in (9.3% vs 27%, P<0.001). The two regimes protocol had a similar positivity rate (70% 3 min vs 73% 6 min, NS) for the detection of CAD. The patients tolerated the 3 min regime better with the most common side effect being flushing. All this is achieved without loss of efficacy of the test. The 3 min regime also uses £25.00 less adenosine per patient.

Citation

Gopinath, G., Buscombe, J., Naojee, S., Szczepura, K., & Hilson, A. (2003). P25. Tolerance and diagnostic accuracy of myocardial scintigraphy with adenosine infusion, 6 min (standard) versus 3 min (abbreviated) protocol. Nuclear Medicine Communications, 24(4), 476. https://doi.org/10.1097/00006231-200304000-00114

• Journal Article Type: Conference Paper
• Conference Name: 31st annual meeting of the British Nuclear Medicine Society
• Conference Location: Manchester, United Kingdom
• Start Date: Apr 29, 2003
• End Date: May 1, 2003
• Publication Date: Apr 1, 2003
• Deposit Date: Feb 26, 2021
• Journal: Nuclear Medicine Communications
• Print ISSN: 0143-3636
• Electronic ISSN: 1473-5628
• Publisher: Lippincott, Williams & Wilkins
• Volume: 24
• Issue: 4
• Pages: 476
• DOI: https://doi.org/10.1097/00006231-200304000-00114
• Publisher URL: https://doi.org/10.1097/00006231-200304000-00114
• Related Public URLs: http://www.nuclearmedicinecomm.com/
• Additional Information: Event Type : Conference