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Healthy passive cigarette smokers have increased pulmonary alveolar permeability

Beadsmoore, C; Cheow, HK; Szczepura, K; Ruparelia, P; Michael Peters, A

Authors

C Beadsmoore

HK Cheow

P Ruparelia

A Michael Peters



Abstract

Question
Does passive smoking have a measurable effect on lung function in otherwise healthy subjects? There is current interest concerning passive smoking but no objective evidence showing that it has any impact on lung function.

Methods
The pulmonary clearance rate of 99mTc-DTPA was measured in 21 healthy volunteers after inhalation as a radio-aerosol and compared between healthy cigarette smokers, passive smokers and non-smokers. All volunteers had normal lung function.

Results
Clearance half-times in healthy passive smokers (n=5) were longer than in healthy smokers (n=6) but clearly shorter compared with healthy non-smokers (n=10) with respective mean values of 45.2 (SD 8.3), 24.3 (8.6) and 80.3 (20) min.

Conclusion
Passive smoking has a functional impact on the lung blood/gas barrier.

Citation

Beadsmoore, C., Cheow, H., Szczepura, K., Ruparelia, P., & Michael Peters, A. (2007). Healthy passive cigarette smokers have increased pulmonary alveolar permeability. Nuclear Medicine Communications, 28(2), 75-77. https://doi.org/10.1097/MNM.0b013e328013eb1e

Journal Article Type Article
Acceptance Date Oct 27, 2006
Publication Date Feb 1, 2007
Deposit Date Feb 26, 2021
Journal Nuclear Medicine Communications
Print ISSN 0143-3636
Electronic ISSN 1473-5628
Publisher Lippincott, Williams & Wilkins
Volume 28
Issue 2
Pages 75-77
DOI https://doi.org/10.1097/MNM.0b013e328013eb1e
Publisher URL https://doi.org/10.1097/MNM.0b013e328013eb1e
Related Public URLs http://www.nuclearmedicinecomm.com/