Moderate intensity exercise in hypoxia increases IGF-1 bioavailability and serum irisin in individuals with type 1 diabetes

Żebrowska, A; Sikora, M; Konarska, A; Zwierzchowska, A; Kamiński, T; Robins, A; Hall, B

Abstract

Aim: This study aimed to determine the effect of moderate intensity continuous exercise (Ex) and hypoxia (Hyp) on serum brain-derived neurotrophic factor (BDNF), insulin-like growth factor-1 (IGF-1) and its binding protein-3 (IGFBP-3), irisin and cytokines levels in patients with type 1 diabetes (T1D). Methods:: A total of 14 individuals with T1D (age: 28.7 ± 7.3 years) and 14 healthy adults (age: 27.1 ± 3.9 years) performed 40-min continuous Ex at moderate intensity (50% lactate threshold) on a cycle ergometer in normoxia (Nor) and Hyp (FiO2 = 15.1%) Biochemical factors, glucose concentrations and physiological variables were measured at rest, immediately and up to 24 h after both Ex protocols. Results:: Patients with T1D had significantly lower pre-Ex serum concentrations of BDNF (p < 0.05, p < 0.01), and total IGF-1 (p < 0.001, p < 0.05) and significantly higher irisin levels (p < 0.05, p < 0.01) in Nor and Hyp, compared with healthy subjects. Ex significantly increased in T1D group serum BDNF (in Nor only p < 0.05) and total IGF-1 levels in Nor and Hyp (p < 0.001 and p < 0.01, respectively). Immediately after Ex in Hyp, freeIGF-1 (p < 0.05) and irisin levels (p < 0.001) were significantly higher compared with the levels induced by Ex alone. Free IGF-1 and irisin serum levels remained elevated in 24 h post-Ex in Hyp. In T1D, significant blood glucose (BG) decrease was observed immediately after Ex in Hyp (p < 0.001) and in 24 h recovery (p < 0.001) compared with pre-Ex level. Conclusion:: The study results suggest that moderate intensity continuous Ex has beneficial effect on BDNF and IGF-1 levels. Ex in hypoxic conditions may be more effective in increasing availability of IGF-1. The alterations in the post-Ex irisin levels and IGF-1 system may be contributing to more effective glycaemia control in patients with T1D.

Citation

Żebrowska, A., Sikora, M., Konarska, A., Zwierzchowska, A., Kamiński, T., Robins, A., & Hall, B. (2020). Moderate intensity exercise in hypoxia increases IGF-1 bioavailability and serum irisin in individuals with type 1 diabetes. Therapeutic Advances in Endocrinology and Metabolism, 11, 2042018820925326. https://doi.org/10.1177/2042018820925326

• Journal Article Type: Article
• Acceptance Date: Apr 21, 2020
• Online Publication Date: May 27, 2020
• Publication Date: May 27, 2020
• Deposit Date: Jun 1, 2020
• Publicly Available Date: Jun 1, 2020
• Journal: Therapeutic Advances in Endocrinology and Metabolism
• Print ISSN: 2042-0188
• Electronic ISSN: 2042-0196
• Publisher: SAGE Publications
• Volume: 11
• Pages: 2042018820925326
• DOI: https://doi.org/10.1177/2042018820925326
• Keywords: Original Research, diabetes, exercise, hypoxia, myokines
• Publisher URL: https://doi.org/10.1177/2042018820925326
• Related Public URLs: http://www.uk.sagepub.com/journals/Journal201936
• Additional Information: Additional Information : ** Embargo end date: 27-05-2020 ** From SAGE Publishing via Jisc Publications Router ** Licence for this article starting on 27-05-2020: https://creativecommons.org/licenses/by-nc/4.0/ **Journal IDs: eissn 2042-0196 **Article IDs: publisher-id: 10.1177_2042018820925326 **History: published_online 27-05-2020; accepted 21-04-2020; submitted 21-01-2020; Funders : Jerzy Kukuczka Academy of Physical Education, Katowice, Poland