NIR-to-NIR two-photon excited CaF2:Tm3+,Yb3+ nanoparticles: multifunctional nanoprobes for highly penetrating fluorescence bio-imaging

Martinez Maestro, L; Dong, N; Pedroni, M; Piccinell, F; Conti, G; Sbarbati, A; Ramı´rez-Herna´ ndez, JE; Iglesias-de la Cruz, MC; Sanz-Rodriguez, F; Juarranz, A; Chen, F; Vetrone, F; Capobianco, JA; Garcia Sole, J; Jaque, D; Bettinelli, M; Speghini, A

Abstract

In this study, we report on the remarkable two-photon excited fluorescence efficiency in the “biological window” of CaF2:Tm3+,Yb3+ nanoparticles. On the basis of the strong Tm3+ ion emission (at around 800 nm), tissue penetration depths as large as 2 mm have been demonstrated, which are more than 4 times those achievable based on the visible emissions in comparable CaF2:Er3+,Yb3+ nanoparticles. The outstanding penetration depth, together with the fluorescence thermal sensitivity demonstrated here, makes CaF2:Tm3+,Yb3+ nanoparticles ideal candidates as multifunctional nanoprobes for high contrast and highly penetrating in vivo fluorescence imaging applications.

Citation

Martinez Maestro, L., Dong, N., Pedroni, M., Piccinell, F., Conti, G., Sbarbati, A., …Speghini, A. (2011). NIR-to-NIR two-photon excited CaF2:Tm3+,Yb3+ nanoparticles: multifunctional nanoprobes for highly penetrating fluorescence bio-imaging. ACS nano, 5(11), 8665-8671. https://doi.org/10.1021/nn202490m

• Journal Article Type: Article
• Acceptance Date: Sep 29, 2011
• Online Publication Date: Oct 6, 2011
• Publication Date: Nov 22, 2011
• Deposit Date: Dec 10, 2019
• Journal: ACS Nano
• Print ISSN: 1936-0851
• Electronic ISSN: 1936-086X
• Publisher: American Chemical Society
• Volume: 5
• Issue: 11
• Pages: 8665-8671
• DOI: https://doi.org/10.1021/nn202490m
• Publisher URL: https://doi.org/10.1021/nn202490m
• Related Public URLs: https://pubs.acs.org/journal/ancac3
• Additional Information: Funders : Universidad Autonoma de Madrid;Comunidad Autonoma de Madrid;Spanish Ministerio de Educacion y Ciencia;Natural Sciences and Engineering Research Council (NSERC) of Canada;Concordia University Research Chairs;Spanish Minsterio de Educaci�on;Fondazione Cariverona (Verona, Italy)