NIR-to-NIR two-photon excited CaF2:Tm3+,Yb3+ nanoparticles: multifunctional nanoprobes for highly penetrating fluorescence bio-imaging

Martinez Maestro, L; Dong, N; Pedroni, M; Piccinell, F; Conti, G; Sbarbati, A; Ramı´rez-Herna´ ndez, JE; Iglesias-de la Cruz, MC; Sanz-Rodriguez, F; Juarranz, A; Chen, F; Vetrone, F; Capobianco, JA; Garcia Sole, J; Jaque, D; Bettinelli, M; Speghini, A

Abstract

In this study, we report on the remarkable two-photon excited fluorescence efficiency in the “biological window” of CaF2:Tm3+,Yb3+ nanoparticles. On the basis of the strong Tm3+ ion emission (at around 800 nm), tissue penetration depths as large as 2 mm have been demonstrated, which are more than 4 times those achievable based on the visible emissions in comparable CaF2:Er3+,Yb3+ nanoparticles. The outstanding penetration depth, together with the fluorescence thermal sensitivity demonstrated here, makes CaF2:Tm3+,Yb3+ nanoparticles ideal candidates as multifunctional nanoprobes for high contrast and highly penetrating in vivo fluorescence imaging applications.

• Journal Article Type: Article
• Acceptance Date: Sep 29, 2011
• Online Publication Date: Oct 6, 2011
• Publication Date: Nov 22, 2011
• Deposit Date: Dec 10, 2019
• Journal: ACS Nano
• Print ISSN: 1936-0851
• Electronic ISSN: 1936-086X
• Publisher: American Chemical Society
• Volume: 5
• Issue: 11
• Pages: 8665-8671
• DOI: https://doi.org/10.1021/nn202490m
• Publisher URL: https://doi.org/10.1021/nn202490m
• Related Public URLs: https://pubs.acs.org/journal/ancac3
• Additional Information: Funders : Universidad Autonoma de Madrid;Comunidad Autonoma de Madrid;Spanish Ministerio de Educacion y Ciencia;Natural Sciences and Engineering Research Council (NSERC) of Canada;Concordia University Research Chairs;Spanish Minsterio de Educaci�on;Fondazione Cariverona (Verona, Italy)