Mechanistic links between obesity, diabetes, and blood pressure : role of perivascular adipose tissue

Saxton, SN; Clark, BJ; Withers, SB; Eringa, EC; Heagerty, AM

Abstract

Obesity is increasingly prevalent and is associated with substantial cardiovascular risk. Adipose tissue distribution and morphology play a key role in determining the degree of adverse effects, and a key factor in the disease process appears to be the inflammatory cell population in adipose tissue. Healthy adipose tissue secretes a number of vasoactive adipokines and anti-inflammatory cytokines, and changes to this secretory profile will contribute to pathogenesis in obesity. In this review, we discuss the links between adipokine dysregulation and the development of hypertension and diabetes and explore the potential for manipulating adipose tissue morphology and its immune cell population to improve cardiovascular health in obesity.

Citation

Saxton, S., Clark, B., Withers, S., Eringa, E., & Heagerty, A. (2019). Mechanistic links between obesity, diabetes, and blood pressure : role of perivascular adipose tissue. Physiological Reviews, 99(4), 1701-1763. https://doi.org/10.1152/physrev.00034.2018

• Journal Article Type: Article
• Acceptance Date: May 4, 2019
• Online Publication Date: Jul 24, 2019
• Publication Date: Oct 1, 2019
• Deposit Date: Oct 11, 2019
• Journal: Physiological Reviews
• Print ISSN: 0031-9333
• Publisher: American Physiological Society
• Volume: 99
• Issue: 4
• Pages: 1701-1763
• DOI: https://doi.org/10.1152/physrev.00034.2018
• Keywords: Physiology (medical), Physiology, Molecular Biology, General Medicine
• Publisher URL: https://doi.org/10.1152/physrev.00034.2018
• Related Public URLs: https://www.physiology.org/journal/physrev
• Additional Information: Additional Information : ** From Crossref via Jisc Publications Router **Journal IDs: pissn 0031-9333; eissn 1522-1210 **History: issued 01-10-2019; published 01-10-2019; Projects : PG/16/52/32229