Switching off malignant mesothelioma : exploiting the hypoxic microenvironment

Nabavi, N; Bennewith, KL; Churg, A; Wang, Y; Collins, CC; Mutti, L

Abstract

Malignant mesotheliomas are aggressive, asbestos-related cancers with poor patient prognosis, typically arising in the mesothelial surfaces of tissues in pleural and peritoneal cavity. The relative unspecific symptoms of mesotheliomas, misdiagnoses, and lack of precise targeted therapies call for a more critical assessment of this disease. In the present review, we categorize commonly identified genomic aberrations of mesotheliomas into their canonical pathways and discuss targeting these pathways in the context of tumor hypoxia, a hallmark of cancer known to render solid tumors more resistant to radiation and most chemo-therapy. We then explore the concept that the intrinsic hypoxic microenvironment of mesotheliomas can be Achilles’ heel for targeted, multimodal therapeutic intervention.

Citation

Nabavi, N., Bennewith, K., Churg, A., Wang, Y., Collins, C., & Mutti, L. (2017). Switching off malignant mesothelioma : exploiting the hypoxic microenvironment. Genes and Cancer, 7(11-12), 340-354. https://doi.org/10.18632/genesandcancer.124

• Journal Article Type: Article
• Acceptance Date: Dec 31, 2016
• Online Publication Date: Jan 1, 2017
• Publication Date: Jan 1, 2017
• Deposit Date: May 14, 2018
• Publicly Available Date: May 14, 2018
• Journal: Genes & Cancer
• Print ISSN: 1947-6019
• Publisher: SAGE Publications
• Volume: 7
• Issue: 11-12
• Pages: 340-354
• DOI: https://doi.org/10.18632/genesandcancer.124
• Publisher URL: https://doi.org/10.18632/genesandcancer.124
• Additional Information: Funders : Canadian Institutes of Health Research;BC Cancer Foundation Mesothelioma Research Fund/Mitacs Accelerate Postdoctoral Fellowship Fund;Terry Fox New Frontiers Program on Prostate Cancer Progression