Role of key players in paradigm shifts of prostate cancer bone metastasis

Sohail, A; Sherin, L; Butt, SI; Javed, S; Li, Z; Iqbal, S; Beg, OA

Abstract

Prostate cancer is one of the most common human cancers and bone metastasis is a frequent finding in the natural history of several types of cancers. The molecular mechanisms that makes prostate cancer metastasize to bone have recently been identified, and provide new molecular targets for drug development, several biochemical by-products that provide insight into the tumorbone interaction, with potential to enhance the clinical management of patients with bone metastases, have been reported during the past decade, however, its anticipated risk, diagnosis and response to therapy are still challenging to assess in clinical practice. In this article, we will discuss these challenges with an emphasis on the communication pathways between each cell type involved and the roles of Wnts, sclerostin, RANKL, PTHrP and macrophages.

• Journal Article Type: Article
• Acceptance Date: Mar 26, 2018
• Online Publication Date: Jun 21, 2018
• Publication Date: Jun 21, 2018
• Deposit Date: Apr 3, 2018
• Publicly Available Date: Jul 17, 2018
• Journal: Cancer Management and Research
• Print ISSN: 1179-1322
• Publisher: Dove Medical Press
• Volume: 2018
• Issue: 10
• Pages: 1619-1626
• DOI: https://doi.org/10.2147/CMAR.S162525
• Publisher URL: https://doi.org/10.2147/CMAR.S162525
• Related Public URLs: https://www.dovepress.com/cancer-management-and-research-journal