Phagocytosis of biocompatible gold nanoparticles

Krpeticc, Z; Porta, F; Caneva, E; Dal Santo, V; Scarì, G

Abstract

We report the evidence for the cellular uptake of gold nanoparticles via the phagocytosis mechanism in murine macrophage cells strongly supported by TEM and optical microscopy. Nanoparticles were prepared using several biocompatible molecules of choice (5-aminovaleric acid, l-DOPA, melatonin, and serotonin hydrochloride) as stabilizers for gold colloids. Their surface chemistry was fully characterized by UV−vis, ATR-FTIR, 1H NMR, and HR-MAS 1H NMR spectroscopies, and size distribution was determined by CPS disc centrifuge and TEM. Differences in coatings were evaluated against cellular uptake, and a preferential movement of macrophages toward 5-aminovaleric acid-modified gold nanoparticles was shown, leading to the fast accumulation of nanoparticles in the cytosol.

Citation

Krpeticc, Z., Porta, F., Caneva, E., Dal Santo, V., & Scarì, G. (2010). Phagocytosis of biocompatible gold nanoparticles. Langmuir, 26(18), 14799-14805. https://doi.org/10.1021/la102758f

• Journal Article Type: Article
• Online Publication Date: Aug 26, 2010
• Publication Date: Aug 26, 2010
• Deposit Date: Oct 11, 2016
• Journal: Langmuir
• Print ISSN: 0743-7463
• Publisher: American Chemical Society
• Volume: 26
• Issue: 18
• Pages: 14799-14805
• DOI: https://doi.org/10.1021/la102758f
• Publisher URL: http://dx.doi.org/10.1021/la102758f
• Related Public URLs: http://pubs.acs.org/doi/abs/10.1021/la102758f
• Additional Information: Funders : Fondazione CARIPLO