Inflicting controlled nonthermal damage to subcellular structures by laser-activated gold nanoparticles

Krpetic, Z; Nativo, P; Sée, V; Prior, IA; Brust, M; Volk, M

Abstract

We show that low-intensity laser irradiation of cancer cells containing endosomal gold nanoparticles leads to endosome rupture and escape of the nanoparticles into the cytosol without affecting the cells’ viability. The low light intensity of our experiments allows us to rule out photothermal effects as the underlying mechanism, and we present results that suggest photoinduced radicals as the photogenerated active species. This nonthermal mechanism may also be important in the context of cell death at higher laser intensities, which had been reported previously.

Citation

Krpetic, Z., Nativo, P., Sée, V., Prior, I., Brust, M., & Volk, M. (2010). Inflicting controlled nonthermal damage to subcellular structures by laser-activated gold nanoparticles. Nano Letters, 10(11), 4549-4554. https://doi.org/10.1021/nl103142t

• Journal Article Type: Article
• Online Publication Date: Oct 5, 2010
• Publication Date: Oct 5, 2010
• Deposit Date: Oct 11, 2016
• Journal: Nano Letters
• Print ISSN: 1530-6984
• Publisher: American Chemical Society
• Volume: 10
• Issue: 11
• Pages: 4549-4554
• DOI: https://doi.org/10.1021/nl103142t
• Publisher URL: http://dx.doi.org/10.1021/nl103142t
• Related Public URLs: http://pubs.acs.org/doi/abs/10.1021/nl103142t
• Additional Information: Funders : European Commission;Biotechnology and Biosciences Sciences Research Council (BBSRC); Projects : NACARDIO;David Phillips Research Fellowship; Grant Number: FP6-LIFESCIHEALTH-37672; Grant Number: BB/C520471/1