Dibenzoyl-methane derivatives as potential and exciting new therapy for the treatment of childhood bone cancer

Almelah, EBM; Smith, D; McGown, AT; Aziz, A; Potgieter, H; Ragazzon, PA

Abstract

Abstract. Childhood bone cancer though rare, has very limited treatment choices, with poor survival rates and often involving amputation. We have developed a novel molecule, 2', 4'-dihydroxy-dithion-dibenzoyl-methane and tested it on hepatic, colon, lung and osteoblasts cancer cell lines. Thionylation of 2', 4'- dihydroxydibenzoylmethane led to selective targeting of bone cancer cells, stopping their growth and leading to their death without affecting non-cancerous cells within the bone marrow or other non-malignant cells.

Citation

Almelah, E., Smith, D., McGown, A., Aziz, A., Potgieter, H., & Ragazzon, P. (2016). Dibenzoyl-methane derivatives as potential and exciting new therapy for the treatment of childhood bone cancer. Anticancer Research, 36(11), 6043-6050. https://doi.org/10.21873/anticanres.11193

• Journal Article Type: Article
• Acceptance Date: May 10, 2016
• Publication Date: Nov 1, 2016
• Deposit Date: May 10, 2016
• Publicly Available Date: May 3, 2017
• Journal: Anticancer Research
• Print ISSN: 0250-7005
• Electronic ISSN: 1791-7530
• Publisher: International Institute of Anticancer Research
• Volume: 36
• Issue: 11
• Pages: 6043-6050
• DOI: https://doi.org/10.21873/anticanres.11193
• Publisher URL: http://dx.doi.org/10.21873/anticanres.11193
• Related Public URLs: http://ar.iiarjournals.org/