Mechanisms of adiponectin-associated perivascular function in vascular disease

Withers, SB; Bussey, CE; Saxton, SN; Melrose, HM; Watkins, AE; Heagerty, AM

Abstract

The concept that fat cells could influence the circulation and indeed cardiac function has been in existence for ≥20 years and has gained a wide interest and no less excitement as evidence has accrued to suggest that such effects may be profound enough to explain disease states, such as hypertension and metabolic changes associated with obesity and type II diabetes mellitus. This ATVB in Focus intends to examine our current knowledge in this field, and suggests mechanisms that may be responsible for normal perivascular function and how they become disordered in obesity. There is the tantalizing prospect of developing new therapeutic approaches to keep obese individuals healthy and redesignating type II diabetes mellitus as a vascular disease.

Citation

Withers, S., Bussey, C., Saxton, S., Melrose, H., Watkins, A., & Heagerty, A. (2014). Mechanisms of adiponectin-associated perivascular function in vascular disease. Arteriosclerosis, Thrombosis, and Vascular Biology, 34(8), 1637-42. https://doi.org/10.1161/ATVBAHA.114.303031

• Journal Article Type: Article
• Acceptance Date: May 2, 2014
• Publication Date: May 22, 2014
• Deposit Date: May 15, 2017
• Journal: Arteriosclerosis, thrombosis, and vascular biology
• Print ISSN: 1079-5642
• Electronic ISSN: 1524-4636
• Publisher: American Heart Association
• Volume: 34
• Issue: 8
• Pages: 1637-42
• DOI: https://doi.org/10.1161/ATVBAHA.114.303031
• Publisher URL: http://dx.doi.org/10.1161/ATVBAHA.114.303031
• Related Public URLs: http://atvb.ahajournals.org/