Asymmetric synthesis of diarylmethane derivatives by dynamic
kinetic resolution

Gooch, LM; Rossington, SB; Wilkinson, JA

Abstract

Asymmetric allylation of ortho-methoxydiphenylmethane has been carried out with high yields and ee of up to 94% using the chiral ligand (−)-sparteine as an additive. Results of reactions performed under various conditions suggest that a dynamic kinetic resolution of two rapidly interconverting diastereomeric complexes is occurring.

Citation

kinetic resolution. Tetrahedron Letters, 56(26), 4025-4027. https://doi.org/10.1016/j.tetlet.2015.05.006

• Journal Article Type: Article
• Acceptance Date: May 2, 2015
• Online Publication Date: May 8, 2015
• Publication Date: Jun 24, 2015
• Deposit Date: Jul 1, 2015
• Journal: Tetrahedron Letters
• Print ISSN: 0040-4039
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 56
• Issue: 26
• Pages: 4025-4027
• DOI: https://doi.org/10.1016/j.tetlet.2015.05.006
• Publisher URL: http://dx.doi.org/10.1016/j.tetlet.2015.05.006
• Related Public URLs: http://www.journals.elsevier.com/tetrahedron-letters