Tetraplex DNA specific ligands based on the fluorenone-carboxamide scaffold

Alcaro, S; Artese, A; Iley, J; Maccari, R; Missailidis, S; Ortuso, F; Octana, R; Ragazzon, PA; Vigorita, M

Abstract

A series of fluorenone-carboxamide compounds was analyzed with regard to DNA binding properties by UV spectroscopy and competition dialysis methods. The morpholino derivative 10 provided interesting results in terms of affinity and specificity toward the DNA G-tetraplex structures. Interactions against this target were evaluated by a comparative molecular modeling study in agreement with the experimental data, proposing a model for the rational design of new agents with potent and selective DNA tetraplex binding properties

Citation

Alcaro, S., Artese, A., Iley, J., Maccari, R., Missailidis, S., Ortuso, F., …Vigorita, M. (2007). Tetraplex DNA specific ligands based on the fluorenone-carboxamide scaffold. Bioorganic and Medicinal Chemistry Letters, 1(17), 2509-2514

• Journal Article Type: Article
• Publication Date: May 1, 2007
• Deposit Date: Jan 26, 2015
• Journal: Bioorganic & Medicinal Chemistry Letters
• Print ISSN: 0960-894X
• Electronic ISSN: 1464-3405
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 1
• Issue: 17
• Pages: 2509-2514
• Publisher URL: http://www.elsevier.com/wps/product/cws_home/972/description
• Related Public URLs: http://www.ncbi.nlm.nih.gov/pubmed/17317164
• Additional Information: Funders : MURST;Open University